Product References
Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation.
Cell reports
Liang D,Jiang L,Bhat SA,Missiroli S,Perrone M,Lauriola A,Adhikari R,Gudur A,Vasi Z,Ahearn I,Guardavaccaro D,Giorgi C,Philips M,Kuchay S
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Tue Jan 31 00:00:00 UTC 2023
FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.
The EMBO journal
Elcocks H,Brazel AJ,McCarron KR,Kaulich M,Husnjak K,Mortiboys H,Clague MJ,Urbé S
71-8700 was used in Western Blot to show that the compound MLN4924, which globally interferes with cullin-RING ligase activity, is a strong inducer of mitophagy, thus providing a research tool in this context and a candidate therapeutic agent for conditions linked to mitochondrial dysfunction.
Mon Jul 03 00:00:00 UTC 2023
An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins.
Science advances
Apte S,Bhutda S,Ghosh S,Sharma K,Barton TE,Dibyachintan S,Sahay O,Roy S,Sinha AR,Adicherla H,Rakshit J,Tang S,Datey A,Santra S,Joseph J,Sasidharan S,Hammerschmidt S,Chakravortty D,Oggioni MR,Santra MK,Neill DR,Banerjee A
71-8700 was used in Western Blot to conclude that exploitation of this generic pathogen sensing strategy allows conservation of host resources and boosts antimicrobial immunity.
Wed Mar 22 00:00:00 UTC 2023
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Cell
Shen JZ,Qiu Z,Wu Q,Finlay D,Garcia G,Sun D,Rantala J,Barshop W,Hope JL,Gimple RC,Sangfelt O,Bradley LM,Wohlschlegel J,Rich JN,Spruck C
71-8700 was used in Immunoprecipitation to demonstrate that FBXO44/SUV39H1 are crucial repressors of RE transcription, and their inhibition selectively induces DNA replication stress and viral mimicry in cancer cells.
Thu Jan 21 00:00:00 UTC 2021
A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation.
Immunity
Liu Z,Nailwal H,Rector J,Rahman MM,Sam R,McFadden G,Chan FK
71-8700 was used in Flow Cytometry to identify a viral inhibitor that binds to the host SKP1-Cullin1-F-box (SCF) machinery and the essential necroptosis kinase receptor interacting protein kinase 3 (RIPK3).
Tue Feb 09 00:00:00 UTC 2021
Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages.
PLoS pathogens
Chadha A,Moreau F,Wang S,Dufour A,Chadee K
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Wed Sep 01 00:00:00 UTC 2021
Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages.
PLoS pathogens
Chadha A,Moreau F,Wang S,Dufour A,Chadee K
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Wed Sep 01 00:00:00 UTC 2021
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Molecular cell
Wang H,Shi H,Rajan M,Canarie ER,Hong S,Simoneschi D,Pagano M,Bush MF,Stoll S,Leibold EA,Zheng N
71-8700 was used in Western Blot to identify an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.
Thu Apr 02 00:00:00 UTC 2020
FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.
Cancer research
Saffie R,Zhou N,Rolland D,Önder Ö,Basrur V,Campbell S,Wellen KE,Elenitoba-Johnson KSJ,Capell BC,Busino L
71-8700 was used in Western Blot to assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms.
Mon Jun 15 00:00:00 UTC 2020
FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.
Cancer research
Saffie R,Zhou N,Rolland D,Önder Ö,Basrur V,Campbell S,Wellen KE,Elenitoba-Johnson KSJ,Capell BC,Busino L
71-8700 was used in Western Blot to assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms.
Mon Jun 15 00:00:00 UTC 2020
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR‑ABL/AKT/mTOR pathway.
International journal of molecular medicine
Zhang Z,Li N,Liu S,Jiang M,Wan J,Zhang Y,Wan L,Xie C,Le A
71-8700 was used in Western Blot to investigate the role of interferon‚induced protein with tetratricopeptde repeats 2 in chronic myeloid leukemia.
Wed Apr 01 00:00:00 UTC 2020
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
Molecular cell
Marzio A,Puccini J,Kwon Y,Maverakis NK,Arbini A,Sung P,Bar-Sagi D,Pagano M
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Thu Jan 17 00:00:00 UTC 2019
Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death.
The EMBO journal
Keuss MJ,Hjerpe R,Hsia O,Gourlay R,Burchmore R,Trost M,Kurz T
71-8700 was used in Western Blotting to show that trimeric, acetylated NEDD8 attenuates PARP-1 activation after oxidative stress, likely to delay the initiation of PARP-1-dependent cell death.
Fri Mar 15 00:00:00 UTC 2019
The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2.
Scientific reports
Correia SP,Chan AB,Vaughan M,Zolboot N,Perea V,Huber AL,Kriebs A,Moresco JJ,Yates JR,Lamia KA
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Thu Jan 17 00:00:00 UTC 2019
Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit.
Nature communications
Sato K,Ito H,Yokoyama A,Toba G,Yamamoto D
71-8700 was used in Immunohistochemistry to demonstrate that partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit in Drosophila.
Fri Jan 11 00:00:00 UTC 2019
The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling.
Cancers
Han S,Shin H,Oh JW,Oh YJ,Her NG,Nam DH
71-8700 was used in Western Blot to suggest that patient-derived glioblastoma stem cells in the context of ERK and AKT activation are sensitive and highly regulated by neddylation inhibition.
Fri Nov 22 00:00:00 UTC 2019
Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.
Nature cell biology
Choi J,Lee K,Ingvarsdottir K,Bonasio R,Saraf A,Florens L,Washburn MP,Tadros S,Green MR,Busino L
71-8700 was used in Western Blotting to elucidate the tumour suppressing mechanism of kelch-like protein 6.
Tue May 01 00:00:00 UTC 2018
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.
Nature
Kuchay S,Giorgi C,Simoneschi D,Pagan J,Missiroli S,Saraf A,Florens L,Washburn MP,Collazo-Lorduy A,Castillo-Martin M,Cordon-Cardo C,Sebti SM,Pinton P,Pagano M
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Thu Jun 22 00:00:00 UTC 2017
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
Journal of cell science
Keuss MJ,Thomas Y,Mcarthur R,Wood NT,Knebel A,Kurz T
71-8700 was used in western blot to analyze the DCN-type NEDD8 E3 ligase mammalian family
Fri Apr 01 00:00:00 UTC 2016
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nature communications
Schlierf A,Altmann E,Quancard J,Jefferson AB,Assenberg R,Renatus M,Jones M,Hassiepen U,Schaefer M,Kiffe M,Weiss A,Wiesmann C,Sedrani R,Eder J,Martoglio B
718700 was used in western blot to identify and characterize an inhibitor of the COP9 signalosome
Mon Oct 24 00:00:00 UTC 2016
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex.
Cell division
Bornstein G,Grossman C
71-8700 was used in western blot to study the effect of neddylation on COP9-Signalosome deneddylase activity
Wed Aug 12 00:00:00 UTC 2015
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
Nature genetics
Gong Y,Zack TI,Morris LG,Lin K,Hukkelhoven E,Raheja R,Tan IL,Turcan S,Veeriah S,Meng S,Viale A,Schumacher SE,Palmedo P,Beroukhim R,Chan TA
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Sun Jun 01 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
71-8700 was used in immunoprecipitation and western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
71-8700 was used in immunoprecipitation and western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
71-8700 was used in immunoprecipitation and western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
71-8700 was used in immunoprecipitation and western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
71-8700 was used in immunoprecipitation and western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
The Journal of biological chemistry
Moroishi T,Yamauchi T,Nishiyama M,Nakayama KI
71-8700 was used in western blot to study the role of HERC2 in FBXL5 degradation and iron metabolism
Fri Jun 06 00:00:00 UTC 2014
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
The Journal of biological chemistry
Moroishi T,Yamauchi T,Nishiyama M,Nakayama KI
71-8700 was used in western blot to study the role of HERC2 in FBXL5 degradation and iron metabolism
Fri Jun 06 00:00:00 UTC 2014
Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Genes & development
Welcker M,Larimore EA,Swanger J,Bengoechea-Alonso MT,Grim JE,Ericsson J,Zheng N,Clurman BE
71-8700 was used in western blot to identify novel functions of Fbw7 dimerization on substrate degradation.
Sun Dec 01 00:00:00 UTC 2013
Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.
Virology
Yu Y,Munger K
71-8700 was used in western blot to study the effect of human papillomavirus type 16 E7 oncoprotein on the anaphase promoting complex/cyclosome and its mechanism
Fri Nov 01 00:00:00 UTC 2013
Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells.
The Journal of biological chemistry
Shimizu N,Nakajima NI,Tsunematsu T,Ogawa I,Kawai H,Hirayama R,Fujimori A,Yamada A,Okayasu R,Ishimaru N,Takata T,Kudo Y
Fri Jun 14 00:00:00 UTC 2013
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.
Cell stem cell
Buckley SM,Aranda-Orgilles B,Strikoudis A,Apostolou E,Loizou E,Moran-Crusio K,Farnsworth CL,Koller AA,Dasgupta R,Silva JC,Stadtfeld M,Hochedlinger K,Chen EI,Aifantis I
Published figure using Cullin 1 polyclonal antibody (Product # 71-8700) in Western Blot
Fri Dec 07 00:00:00 UTC 2012
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Nature structural & molecular biology
den Besten W,Verma R,Kleiger G,Oania RS,Deshaies RJ
71-8700 was used in western blot to show that NEDD8 links CRL ubiquitin ligase function to the p97 pathway.
Sun Apr 01 00:00:00 UTC 2012
Cullin-3 regulates late endosome maturation.
Proceedings of the National Academy of Sciences of the United States of America
Huotari J,Meyer-Schaller N,Hubner M,Stauffer S,Katheder N,Horvath P,Mancini R,Helenius A,Peter M
Tue Jan 17 00:00:00 UTC 2012
β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.
Molecular and cellular biology
Cui W,Xiao N,Xiao H,Zhou H,Yu M,Gu J,Li X
71-8700 was used in western blot to report that the SCF-β-TrCP complex functions as the K48-linked ubiquitination E3 ligase for IRAK.
Mon Oct 01 00:00:00 UTC 2012
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
BMC biology
Bandau S,Knebel A,Gage ZO,Wood NT,Alexandru G
Thu Apr 26 00:00:00 UTC 2012
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.
Molecular and cellular biology
Tan MK,Lim HJ,Harper JW
71-8700 was used in western blot to study the effect of SCF on histone H3 lysine 9 and 36 methylation and its mechanism
Thu Sep 01 00:00:00 UTC 2011
The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
The Journal of biological chemistry
Fernandez-Sanchez ME,Sechet E,Margottin-Goguet F,Rogge L,Bianchi E
71-8700 was used in western blot to explore how the COP9 signalosome affects ubiquitination processes
Fri Jun 04 00:00:00 UTC 2010
The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
The Journal of biological chemistry
Fernandez-Sanchez ME,Sechet E,Margottin-Goguet F,Rogge L,Bianchi E
71-8700 was used in western blot to explore how the COP9 signalosome affects ubiquitination processes
Fri Jun 04 00:00:00 UTC 2010
The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
The Journal of biological chemistry
Fernandez-Sanchez ME,Sechet E,Margottin-Goguet F,Rogge L,Bianchi E
71-8700 was used in western blot to explore how the COP9 signalosome affects ubiquitination processes
Fri Jun 04 00:00:00 UTC 2010
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.
The Journal of biological chemistry
Glenn KA,Nelson RF,Wen HM,Mallinger AJ,Paulson HL
71-8700 was used in western blot to assess the substrate specificity of the FBA family
Fri May 09 00:00:00 UTC 2008
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.
The Journal of biological chemistry
Glenn KA,Nelson RF,Wen HM,Mallinger AJ,Paulson HL
71-8700 was used in western blot to assess the substrate specificity of the FBA family
Fri May 09 00:00:00 UTC 2008
Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
The Journal of biological chemistry
Ang XL,Seeburg DP,Sheng M,Harper JW
71-8700 was used in western blot to demonstrate that the SCF(beta-TRCP) complex targets the postsynaptic spine-associated Rap GTPase activating protein for degradation in neurons
Fri Oct 24 00:00:00 UTC 2008
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nelson RF,Glenn KA,Zhang Y,Wen H,Knutson T,Gouvion CM,Robinson BK,Zhou Z,Yang B,Smith RJ,Paulson HL
71-8700 was used in western blot to investigate the role of Fbx2 in ear homeostasis
Wed May 09 00:00:00 UTC 2007
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
Molecular and cellular biology
Tian Y,Kolb R,Hong JH,Carroll J,Li D,You J,Bronson R,Yaffe MB,Zhou J,Benjamin T
71-8700 was used in western blot to use knockout mice and zebrafish to study the contribution of TAZ to polycystic kidney disease
Sat Sep 01 00:00:00 UTC 2007
Substrate-mediated regulation of cullin neddylation.
The Journal of biological chemistry
Chew EH,Hagen T
71-8700 was used in Western Blotting to suggest a mechanism through which availability of substrate recognition subunits and substrates can regulate the ubiquitin ligase activity.
Fri Jun 08 00:00:00 UTC 2007
Substrate-mediated regulation of cullin neddylation.
The Journal of biological chemistry
Chew EH,Hagen T
71-8700 was used in Western Blotting to suggest a mechanism through which availability of substrate recognition subunits and substrates can regulate the ubiquitin ligase activity.
Fri Jun 08 00:00:00 UTC 2007
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
Proceedings of the National Academy of Sciences of the United States of America
Bornstein G,Ganoth D,Hershko A
71-8700 was used in western blot to elucidate the mechanisms that regulate neddylation and deneddylation of cullins
Tue Aug 01 00:00:00 UTC 2006
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
The Journal of biological chemistry
Denti S,Fernandez-Sanchez ME,Rogge L,Bianchi E
71-8700 was used in western blot to examine how the COP9 signalosome regulates the cell cycle in human cells
Fri Oct 27 00:00:00 UTC 2006
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
The Journal of biological chemistry
Denti S,Fernandez-Sanchez ME,Rogge L,Bianchi E
71-8700 was used in western blot to examine how the COP9 signalosome regulates the cell cycle in human cells
Fri Oct 27 00:00:00 UTC 2006
A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.
The Journal of biological chemistry
Nelson RF,Glenn KA,Miller VM,Wen H,Paulson HL
71-8700 was used in western blot to study CHIP and Fbx2 interactions
Fri Jul 21 00:00:00 UTC 2006
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
The Journal of biological chemistry
Shirogane T,Jin J,Ang XL,Harper JW
Fri Jul 22 00:00:00 UTC 2005
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
The Journal of biological chemistry
Shirogane T,Jin J,Ang XL,Harper JW
Fri Jul 22 00:00:00 UTC 2005
Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.
The Journal of biological chemistry
Tomoda K,Yoneda-Kato N,Fukumoto A,Yamanaka S,Kato JY
Fri Oct 08 00:00:00 UTC 2004
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
Nature
Busino L,Donzelli M,Chiesa M,Guardavaccaro D,Ganoth D,Dorrello NV,Hershko A,Pagano M,Draetta GF
Thu Nov 06 00:00:00 UTC 2003
The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.
BMC cell biology
Lu L,Schulz H,Wolf DA
71-8700 was used in western blot to assess the role of the SKP2 F-box protein in p27 regulation in prostate cancer.
Tue Aug 20 00:00:00 UTC 2002
A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo.
The Journal of biological chemistry
Wada H,Yeh ET,Kamitani T
71-8700 was used in western blot to investigate the relationship between NEDD8 and UBC2.
Fri Jun 02 00:00:00 UTC 2000
A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo.
The Journal of biological chemistry
Wada H,Yeh ET,Kamitani T
71-8700 was used in western blot to investigate the relationship between NEDD8 and UBC2.
Fri Jun 02 00:00:00 UTC 2000
The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
The Journal of biological chemistry
Wada H,Yeh ET,Kamitani T
71-8700 was used in Western Blotting to conclude that the VBC complex appears to have ligase activity in the conjugation of NEDD8 to Cul-2.
Fri Dec 10 00:00:00 UTC 1999
