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Cullin 5 Polyclonal Antibody
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Cullin 5 Antibody (OSC00210W-100UL) in IHC (P)
IHC on rat spinal cord (paraffin section) using Rabbit antibody to n-terminal of Cullin 5 (Vasopressin activated calcium-mobilizing receptor 1): whole serum (OSC00210W) at 1 : 200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin.
Product Details
OSC00210W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the n-terminal of human Cullin 5 (Vasopressin activated calcium-mobilizing receptor 1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Cullin 5.
Target Information
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CUL-5; Cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
Gene Aliases: 4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; VACM-1; VACM1
UniProt ID: (Human) Q93034, (Rat) Q9JJ31, (Mouse) Q9D5V5
Entrez Gene ID: (Human) 8065, (Rat) 64624, (Mouse) 75717
G1/S transition of mitotic cell cycle
cell cycle arrest
cell proliferation
negative regulation of cell proliferation
viral process
ERBB2 signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
calcium ion transmembrane transport
intrinsic apoptotic signaling pathway
protein polyubiquitination
ubiquitin-dependent protein catabolic process
response to osmotic stress
G-protein coupled receptor signaling pathway
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
regulation of cytosolic calcium ion concentration
Performance Guarantee
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