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Cyclin B2 Polyclonal Antibody

Cyclin B2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cyclin B2 Antibody (21644-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 21644-1-AP ( Cyclin B2 antibody at dilution of 1:200 (under 40x lens).

Cyclin B2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21644-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cyclin B2 Fusion Protein Ag16329 (1-243 aa encoded by BC105086)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MALLRRPTV SSDLENIDTG VNSKVKSHVT IRRTVLEEIG NRVTTRAAQV AKKAQNTKVP VQPTKTTNVN KQLKPTASVK PVQMEKLAPK GPSPTPEDVS MKEENLCQAF SDALLCKIED IDNEDWENPQ LCSDYVKDIY QYLRQLEVLQ SINPHFLDGR DINGRMRAIL VDWLVQVHSK FRLLQETLYM CVGIMDRFLQ VQPVSRKKLQ LVGITALLLA SKYEEMFSPN IEDFVYITDN AYTS (1-243 aa encoded by BC105086)

Target Information

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Chen C,Chen J,Wang Y,Fang L,Guo C,Sang T,Peng H,Zhao Q,Chen S,Lin X,Wang X

Wed Feb 01 00:00:00 UTC 2023

Identification of a transcription factor‑cyclin family genes network in lung adenocarcinoma through bioinformatics analysis and validation through RT‑qPCR.

Experimental and therapeutic medicine

Yang X,Zhou Y,Ge H,Tian Z,Li P,Zhao X

Sun Jan 01 00:00:00 UTC 2023

Identification of a transcription factor‑cyclin family genes network in lung adenocarcinoma through bioinformatics analysis and validation through RT‑qPCR.

Experimental and therapeutic medicine

Yang X,Zhou Y,Ge H,Tian Z,Li P,Zhao X

Sun Jan 01 00:00:00 UTC 2023

Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Liu FJ,Chen XY,Yang J,Zhao Z,Wang QL,Li P,Jiang Y,Li HJ

Wed Feb 01 00:00:00 UTC 2023

Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.

Ecotoxicology and environmental safety

Su L,Fang W,Zhao X,Zhu L,Gao L,Chen G

Wed Jun 01 00:00:00 UTC 2022

Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.

Ecotoxicology and environmental safety

Li F,Wang Y,Xu M,Hu N,Miao J,Zhao Y,Wang L

Sat Oct 15 00:00:00 UTC 2022

Protective role of m⁶A binding protein YTHDC2 on CCNB2 in manganese-induced spermatogenesis dysfunction.

Chemico-biological interactions

Qi Z,Liu Y,Yang H,Yang X,Wang H,Liu B,Yuan Y,Wang G,Xu B,Liu W,Xu Z,Deng Y

Wed Jan 05 00:00:00 UTC 2022

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint.

EMBO reports

Liu S,Yuan X,Gui P,Liu R,Durojaye O,Hill DL,Fu C,Yao X,Dou Z,Liu X

Tue Jun 07 00:00:00 UTC 2022

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint.

EMBO reports

Liu S,Yuan X,Gui P,Liu R,Durojaye O,Hill DL,Fu C,Yao X,Dou Z,Liu X

Tue Jun 07 00:00:00 UTC 2022

Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation.

Oxidative medicine and cellular longevity

Cao M,Ma R,Li H,Cui J,Zhang C,Zhao J

Mon Apr 04 00:00:00 UTC 2022

miR-550a-5p promotes the proliferation and migration of hepatocellular carcinoma by targeting GNE via the Wnt/β-catenin signaling pathway.

Neoplasma

Li CM,Wu W,Zhu Z,Lu PL,Gong JP,Ma R

Thu Dec 01 00:00:00 UTC 2022

Identifying and Validating Potential Biomarkers of Early Stage Lung Adenocarcinoma Diagnosis and Prognosis.

Frontiers in oncology

Chen Y,Jin L,Jiang Z,Liu S,Feng W

Fri Apr 22 00:00:00 UTC 2022

N6-methyladenosine regulates ATM expression and downstream signaling.

Journal of Cancer

Zhang X,Liu P,Zheng X,Wang J,Peng Q,Li Z,Wei L,Liu C,Wu Y,Wen Y,Yan Q,Ma J

Sat Aug 17 00:00:00 UTC 2024

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.

eLife

Lin XT,Yu HQ,Fang L,Tan Y,Liu ZY,Wu D,Zhang J,Xiong HJ,Xie CM

Mon Nov 15 00:00:00 UTC 2021

ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.

Journal of experimental & clinical cancer research : CR

Sun X,He Z,Guo L,Wang C,Lin C,Ye L,Wang X,Li Y,Yang M,Liu S,Hua X,Wen W,Lin C,Long Z,Zhang W,Li H,Jian Y,Zhu Z,Wu X,Lin H

Fri Apr 30 00:00:00 UTC 2021

Identification of biomarkers for the transition from low-grade glioma to secondary glioblastoma by an integrated bioinformatic analysis.

American journal of translational research

Zhao L,Zhang J,Liu Z,Zhao P

Mon Sep 28 00:00:00 UTC 2020

ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.

OncoTargets and therapy

Ye Z,Zeng Z,Shen Y,Yang Q,Chen D,Chen Z,Shen S

Thu Oct 01 00:00:00 UTC 2020

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.

Molecular medicine reports

Wang AL,Li Y,Zhao Q,Fan LQ

Fri Jun 01 00:00:00 UTC 2018

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.

Molecular medicine reports

Wang AL,Li Y,Zhao Q,Fan LQ

Fri Jun 01 00:00:00 UTC 2018

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Oncotarget

Fan L,Cao X,Yan H,Wang Q,Tian X,Zhang L,He X,Borjihan G

Tue Jul 18 00:00:00 UTC 2017

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Oncotarget

Fan L,Cao X,Yan H,Wang Q,Tian X,Zhang L,He X,Borjihan G

Tue Jul 18 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: G2/mitotic-specific cyclin B2; G2/mitotic-specific cyclin-B2

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Gene Aliases: CCNB2; CycB2; HsT17299

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UniProt ID: (Human) O95067, (Mouse) P30276

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Entrez Gene ID: (Human) 9133, (Rat) 363088, (Mouse) 12442

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Function(s)

cyclin-dependent protein serine/threonine kinase activity protein binding cadherin binding involved in cell-cell adhesion

Process(es)

G2/M transition of mitotic cell cycle in utero embryonic development mitotic nuclear division mitotic nuclear envelope disassembly growth T cell homeostasis thymus development cell division regulation of cell cycle cell-cell adhesion cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cyclin B2 Polyclonal Antibody

Cyclin B2 Antibody (21644-1-AP) in IHC (P)

Product Details

21644-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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