Proteintech

Cyclin D3 Polyclonal Antibody

Cyclin D3 Antibody in Immunocytochemistry (ICC/IF)

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Cyclin D3 Antibody (26755-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 26755-1-AP (Cyclin D3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Cyclin D3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cyclin D3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

26755-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cyclin D3 Fusion Protein Ag25151 (250-292 aa encoded by BC011616)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ALRESLREA SQTSSSPAPK APRGSSSQGP SQTSTPTDVT AIHL (250-292 aa encoded by B C011616)

Target Information

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.

BMC cancer

Gao X,Jiang P,Wei X,Zhang W,Zheng J,Sun S,Yao H,Liu X,Zhang Q

Wed Feb 15 00:00:00 UTC 2023

Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation.

Acta pharmacologica Sinica

Xu YJ,Zeng K,Ren Y,Mao CY,Ye YH,Zhu XT,Sun ZY,Cao BY,Zhang ZB,Xu GQ,Huang ZQ,Mao XL

Fri Sep 01 00:00:00 UTC 2023

Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation.

Acta pharmacologica Sinica

Xu YJ,Zeng K,Ren Y,Mao CY,Ye YH,Zhu XT,Sun ZY,Cao BY,Zhang ZB,Xu GQ,Huang ZQ,Mao XL

Fri Sep 01 00:00:00 UTC 2023

Knockdown of FGFR3 inhibits the proliferation, migration and invasion of intrahepatic cholangiocarcinoma.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Chen YH,Yang SH,Liu LX,Hu S,Wang XJ,Liao ZJ,Huan YF,He K,Zhang XW

Wed Mar 01 00:00:00 UTC 2023

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.

Thoracic cancer

Zhou D,Liu T,Rao X,Jie X,Chen Y,Wu Z,Deng H,Zhang D,Wang J,Wu G

Mon May 01 00:00:00 UTC 2023

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.

Thoracic cancer

Zhou D,Liu T,Rao X,Jie X,Chen Y,Wu Z,Deng H,Zhang D,Wang J,Wu G

Mon May 01 00:00:00 UTC 2023

PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.

Cell & bioscience

Chen L,Dong W,Zhou M,Yang C,Xiong M,Kazobinka G,Chen Z,Xing Y,Hou T

Mon Mar 06 00:00:00 UTC 2023

PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.

Cell & bioscience

Chen L,Dong W,Zhou M,Yang C,Xiong M,Kazobinka G,Chen Z,Xing Y,Hou T

Mon Mar 06 00:00:00 UTC 2023

HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.

Journal of experimental & clinical cancer research : CR

Guo K,Ma Z,Zhang Y,Han L,Shao C,Feng Y,Gao F,Di S,Zhang Z,Zhang J,Tabbò F,Ekman S,Suda K,Cappuzzo F,Han J,Li X,Yan X

Fri Mar 11 00:00:00 UTC 2022

The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1.

Cell death discovery

Lu D,Di S,Zhuo S,Zhou L,Bai R,Ma T,Zou Z,Chen C,Sun M,Tang J,Zhang Z

Mon Mar 01 00:00:00 UTC 2021

Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.

Molecular biology of the cell

Sharma P,Tiufekchiev S,Lising V,Chung SW,Suk JS,Chung BM

Mon Nov 01 00:00:00 UTC 2021

Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3.

Cell death & disease

Zhuo S,Sun M,Bai R,Lu D,Di S,Ma T,Zou Z,Li H,Zhang Z

Sat May 15 00:00:00 UTC 2021

GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.

Cell death & disease

Zhou C,Du J,Zhao L,Liu W,Zhao T,Liang H,Fang P,Zhang K,Zeng H

Wed Mar 03 00:00:00 UTC 2021

ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.

Molecular and cellular endocrinology

Ma L,Li C,Lian S,Xu B,Yuan J,Lu J,Yang H,Guo J,Ji H

Fri Jan 01 00:00:00 UTC 2021

Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.

Cell death discovery

Zhou B,Ge Y,Shao Q,Yang L,Chen X,Jiang G

Sat Jun 26 00:00:00 UTC 2021

Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1.

Translational lung cancer research

Zhang Z,Cui Z,Xie Z,Li C,Xu C,Guo X,Yu J,Chen T,Facchinetti F,Bohnenberger H,Leong TL,Xie Y,Mao X,Zhao J

Fri Oct 01 00:00:00 UTC 2021

Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells.

Journal of proteome research

Delfarah A,Hartel NG,Zheng D,Yang J,Graham NA

Fri Nov 05 00:00:00 UTC 2021

S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.

Molecular therapy oncolytics

He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M

Wed Dec 16 00:00:00 UTC 2020

Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.

Cancer gene therapy

Dong M,Xiao Q,Hu J,Cheng F,Zhang P,Zong W,Tang Q,Li X,Mao F,He Y,Yu X,Wan F,Lei T,Guo D,Wang B

Tue Dec 01 00:00:00 UTC 2020

Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21^Cip1 and p27^Kip1.

Journal of cellular and molecular medicine

Zhang D,Fan R,Lei L,Lei L,Wang Y,Lv N,Chen P,Williamson RA,Wang B,Hu J

Sat Aug 01 00:00:00 UTC 2020

Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing.

International journal of molecular medicine

Zhu X,Feng J,Fu W,Shu X,Wan X,Liu J

Mon Jun 01 00:00:00 UTC 2020

Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism.

Cell death discovery

Zhao J,Ma Y,Zhang Y,Fu B,Wu X,Li Q,Cai G,Chen X,Bai XY

Thu Oct 01 00:00:00 UTC 2020

Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.

Experimental eye research

Zheng M,Tian C,Fan T,Xu B

Thu Aug 01 00:00:00 UTC 2019

Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sun Z,Liu Y,Yu F,Xu Y,Yanli L,Liu N

Mon Jul 01 00:00:00 UTC 2019

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.

BMC cancer

Liu W,Fan Y,Shi Y,Lin Z,Huang X,Huang W,Shen D,Qi Z

Wed Aug 29 00:00:00 UTC 2018

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.

BMC cancer

Liu W,Fan Y,Shi Y,Lin Z,Huang X,Huang W,Shen D,Qi Z

Wed Aug 29 00:00:00 UTC 2018

Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma X,Jiang C,Li Y,Feng L,Liu J,Wang J

Fri Sep 01 00:00:00 UTC 2017

Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma X,Jiang C,Li Y,Feng L,Liu J,Wang J

Fri Sep 01 00:00:00 UTC 2017

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21^Waf1/Cip1 and p27^Kip1.

Taiwanese journal of obstetrics & gynecology

Zhou Y,Wang K,Zhen S,Wang R,Luo W

Thu Dec 01 00:00:00 UTC 2016

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21^Waf1/Cip1 and p27^Kip1.

Taiwanese journal of obstetrics & gynecology

Zhou Y,Wang K,Zhen S,Wang R,Luo W

Thu Dec 01 00:00:00 UTC 2016

The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma.

PloS one

Furuta M,Kozaki K,Tanimoto K,Tanaka S,Arii S,Shimamura T,Niida A,Miyano S,Inazawa J

Tue Sep 17 00:00:00 UTC 2013

The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma.

PloS one

Furuta M,Kozaki K,Tanimoto K,Tanaka S,Arii S,Shimamura T,Niida A,Miyano S,Inazawa J

Tue Sep 17 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: CCND 3; CGD3; CyclinD3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3

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Gene Aliases: CCND3

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UniProt ID: (Human) P30281, (Rat) P48961

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Entrez Gene ID: (Human) 896, (Rat) 25193

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Function(s)

cyclin-dependent protein serine/threonine kinase activity protein binding protein kinase binding

Process(es)

positive regulation of protein phosphorylation cell cycle signal transduction T cell proliferation positive regulation of cyclin-dependent protein serine/threonine kinase activity cell division G1/S transition of mitotic cell cycle protein phosphorylation positive regulation of cell proliferation response to glucose response to organic substance hyaluronan biosynthetic process response to peptide hormone regulation of cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cyclin D3 Polyclonal Antibody

Cyclin D3 Antibody (26755-1-AP) in ICC/IF

Product Details

26755-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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