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Progen
Cyclin D3 Monoclonal Antibody (DCS-22)
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Cyclin D3 Antibody (61064PROGEN) in IHC (P)
Immunohistochemistry analysis of human endocrine epithelial cells of the islets of Langerhans of the pancreas using anti-Cyclin D3 antibody (Cat. No. 61064). IHC was performed on formalin fixed paraffin embedded sections. The samples were deparaffinized with xylol and ethanol followed by heat induced antigen retrieval with 10 mM citrate buffer. After preparation the tissue was blocked with normal serum for ... View More
Product Details
61064PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DCS-22
Immunogen
Human Recombinant Cyclin D3 Protein
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
DCS-22 reacts specifically with cyclin D3. The antibody is useful for analysis of proliferation, detec-tion of cyclin D3 on tissue sections (suspected oncogene) and in cell cycle studies. The antibody does not cross-react with cyclin D1 and cyclin D2. Complementary reaction to the anti-cyclin D1/D2 antibodies.
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCND 3; CGD3; CyclinD3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
Gene Aliases: 9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND3; Cyl-3
UniProt ID: (Human) P30281, (Mouse) P30282
Entrez Gene ID: (Human) 896, (Mouse) 12445
positive regulation of protein phosphorylation
protein phosphorylation
cell cycle
signal transduction
positive regulation of cell proliferation
hyaluronan biosynthetic process
T cell proliferation
response to peptide hormone
positive regulation of cyclin-dependent protein serine/threonine kinase activity
cell division
regulation of cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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