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Alomone Labs, LTD
CysLTR1 (extracellular) Polyclonal Antibody
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CysLTR1 (extracellular) Antibody (ALR-003-200UL) in WB
Western blot analysis of acute monocytic leukemia THP-1 (lanes 1 and 4), promyelocytic leukemia HL-60 (lanes 2 and 5) and acute T-cell leukemia Jurkat (lanes 3 and 6) human cell lysates: - 1,2,3. Anti-CysLTR1 (extracellular) Antibody (#ALR-003), (1:200).4,5,6. Anti-CysLTR1 (extracellular) Antibody , preincubated with CysLTR1 (extracellular) Blocking Peptide (#BLP-LR003).
Product Details
ALR-003-200UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HNETKP(S)DSVLRMQK, corresponding to amino acid residues 261-275 of human CysLTR1, 3rd extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cys-LT1 receptor; CysLT 1; CysLT(1); CysLT1 receptor; CysLTR1; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; LTD4R; MGC46139
Gene Aliases: CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; HMTMF81
UniProt ID: (Human) Q9Y271
Entrez Gene ID: (Human) 10800
circulatory system process
calcium ion transport
chemotaxis
defense response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
respiratory gaseous exchange
leukotriene signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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