Proteintech

Cystatin C Polyclonal Antibody

Cystatin C Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

Cystatin C Antibody (12245-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 12245-1-AP (Cystatin C antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Cystatin C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cystatin C Antibody in Western Blot (WB)

Cystatin C Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12245-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cystatin C Fusion Protein Ag2890 (25-146 aa encoded by BC013083)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AGSSPGKPP RLVGGPMDAS VEEEGVRRAL DFAVGEYNKA SNDMYHSRAL QVVRARKQIV AGVNYFLDVE LGRTTCTKTQ PNLDNCPFHD QPHLKRKAFC SFQIYAVPWQ GTMTLSKSTC QDA (25-146 aa encoded by BC013083)

Target Information

Cystatin C, a member of the type 2 cystatin superfamily, is a potent inhibitor of cysteine proteinases, both endogenous (lysosomal cathepsins), and pathogenic. Cystatin C is a 13 kDa secreted protein which is found in high concentrations in biological fluids and is thought to be expressed by all human nucleated cells. Changes in Cystatin C have been documented in a number of cardiovascular diseases, including atherosclerosis, amyloid angiopathy and myocardial infarction. Its low molecular weight also means that Cystatin C can be used as a marker of renal failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dioscin ameliorates silica-aggravated systemic lupus erythematosus via suppressing apoptosis and improving LC3-associated phagocytosis in MRL/lpr mice.

International immunopharmacology

Zhang P,Lei X,Ou L,Cheng Y,Miao Q,Li C,Chen Y

Wed Mar 01 00:00:00 UTC 2023

Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.

Experimental cell research

Li Z,Jin T,Yang R,Guo J,Niu Z,Gao H,Song X,Zhang Q,Ning Z,Ren L,Wang Y,Fan X,Liang H,Li T,He W

Fri Sep 01 00:00:00 UTC 2023

Clinicopathological diversity of semantic dementia: Comparisons of patients with early-onset versus late-onset, left-sided versus right-sided temporal atrophy, and TDP-type A versus type C pathology.

Neuropathology : official journal of the Japanese Society of Neuropathology

Kawakatsu S,Kobayashi R,Morioka D,Hayashi H,Utsunomiya A,Kabasawa T,Ohe R,Futakuchi M,Otani K

Wed Feb 01 00:00:00 UTC 2023

Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.

Journal of ethnopharmacology

Zhang X,Wang S,Jin Y,Wang J,Wang R,Yang X,Zhang S,Yan T,Jia Y

Tue May 23 00:00:00 UTC 2023

CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.

Biochemical and biophysical research communications

Teng S,Liu G,Li L,Ou J,Yu Y

Sat Jun 11 00:00:00 UTC 2022

A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.

Journal of cellular and molecular medicine

Tai H,Tong YJ,Yu R,Yu Y,Yao SC,Li LB,Liu Y,Cui XZ,Kuang JS,Meng XS,Jiang XL

Wed Jun 01 00:00:00 UTC 2022

Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.

Frontiers in pharmacology

Wang J,Wang K,Ding L,Zhao P,Zhang C,Wang H,Yang Z,Liu Z

Tue Sep 03 00:00:00 UTC 2024

Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Aging

Jiang XL,Tai H,Kuang JS,Zhang JY,Cui SC,Lu YX,Qi SB,Zhang SY,Li SM,Chen JP,Meng XS

Thu Oct 27 00:00:00 UTC 2022

Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.

Biosensors & bioelectronics

Chen YJ,Hsu YP,Tain YL,Li NS,Pang HH,Kuo SW,Yang HW

Fri Jul 15 00:00:00 UTC 2022

Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.

Aging

Tai H,Cui XZ,He J,Lan ZM,Li SM,Li LB,Yao SC,Jiang XL,Meng XS,Kuang JS

Thu Oct 20 00:00:00 UTC 2022

Dopamine Transporter Imaging for Frontotemporal Lobar Degeneration With Motor Neuron Disease.

Frontiers in neuroscience

Kobayashi R,Kawakatsu S,Ohba M,Morioka D,Kanoto M,Otani K

Sun Aug 25 00:00:00 UTC 2024

Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells.

The international journal of biochemistry & cell biology

Feng W,Wang J,Li B,Liu Y,Xu D,Cheng K,Zhuang J

Sun May 01 00:00:00 UTC 2022

Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.

Frontiers in endocrinology

Jiang XL,Tai H,Xiao XS,Zhang SY,Cui SC,Qi SB,Hu DD,Zhang LN,Kuang JS,Meng XS,Li SM

Tue Dec 06 00:00:00 UTC 2022

Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.

BMC complementary medicine and therapies

Tai H,Jiang XL,Lan ZM,Li Y,Kong L,Yao SC,Song N,Lv MJ,Wu J,Yang P,Xiao XS,Yang GL,Kuang JS,Jia LQ

Mon Mar 22 00:00:00 UTC 2021

Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca²⁺ homeostasis.

Cell biology and toxicology

Zhong Y,Jin C,Han J,Zhu J,Liu Q,Sun D,Xia X,Peng X

Fri Oct 01 00:00:00 UTC 2021

Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca²⁺ Homeostasis, and Bcl2 Expression.

Molecular nutrition & food research

Zhong Y,Jin C,Han J,Zhu J,Liu Q,Sun D,Xia X,Zhang Y,Peng X

Sun Aug 01 00:00:00 UTC 2021

Icaritin protects SH-SY5Y cells transfected with TDP-43 by alleviating mitochondrial damage and oxidative stress.

PeerJ

Zhou Y,Huang N,Li Y,Ba Z,Zhou Y,Luo Y

Tue Apr 26 00:00:00 UTC 2022

Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.

Journal of hazardous materials

Xiaoli F,Yaqing Z,Ruhui L,Xuan L,Aijie C,Yanli Z,Chen H,Lili C,Longquan S

Sun Aug 15 00:00:00 UTC 2021

Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.

Frontiers in medicine

Tai H,Jiang XL,Song N,Xiao HH,Li Y,Cheng MJ,Yin XM,Chen YR,Yang GL,Jiang XY,Kuang JS,Lan ZM,Jia LQ

Sat May 22 00:00:00 UTC 2021

Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats.

Evidence-based complementary and alternative medicine : eCAM

Li S,Dong J,Ta G,Liu Y,Cui J,Li X,Song J,Liu A,Cheng G

Thu Mar 28 00:00:00 UTC 2024

Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.

Experimental and therapeutic medicine

Yan B,Zhang X,Wang J,Jia S,Zhou Y,Tian J,Wang H,Tang Y

Thu Oct 01 00:00:00 UTC 2020

Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.

Experimental and therapeutic medicine

Yan B,Zhang X,Wang J,Jia S,Zhou Y,Tian J,Wang H,Tang Y

Thu Oct 01 00:00:00 UTC 2020

LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.

Journal of cellular and molecular medicine

Xie LB,Chen B,Liao X,Chen YF,Yang R,He SR,Pei LJ,Jiang R

Fri May 01 00:00:00 UTC 2020

Mitophagy in the Hippocampus Is Excessive Activated After Cardiac Arrest and Cardiopulmonary Resuscitation.

Neurochemical research

Huang Y,Gao X,Zhou X,Xie B,Zhang Y,Zhu J,Zhu S

Sat Feb 01 00:00:00 UTC 2020

SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.

Journal of Cancer

Zhang R,Wang C,Tian Y,Yao Y,Mao J,Wang H,Li Z,Xu Y,Ye M,Wang L

Thu Oct 01 00:00:00 UTC 2020

Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.

Environmental pollution (Barking, Essex : 1987)

Ma J,Li X

Thu Nov 01 00:00:00 UTC 2018

Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.

Environmental pollution (Barking, Essex : 1987)

Ma J,Li X

Thu Nov 01 00:00:00 UTC 2018

Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.

Environmental pollution (Barking, Essex : 1987)

Ma J,Li X

Thu Nov 01 00:00:00 UTC 2018

Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.

Environmental pollution (Barking, Essex : 1987)

Ma J,Li X

Thu Nov 01 00:00:00 UTC 2018

Total protein is an effective loading control for cerebrospinal fluid western blots.

Journal of neuroscience methods

Collins MA,An J,Peller D,Bowser R

Sat Aug 15 00:00:00 UTC 2015

Total protein is an effective loading control for cerebrospinal fluid western blots.

Journal of neuroscience methods

Collins MA,An J,Peller D,Bowser R

Sat Aug 15 00:00:00 UTC 2015

Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.

International journal of clinical and experimental pathology

Yan Y,Zhou K,Wang L,Zhou Y,Chen X,Fan Q

Wed Oct 05 00:00:00 UTC 2016

Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.

International journal of clinical and experimental pathology

Yan Y,Zhou K,Wang L,Zhou Y,Chen X,Fan Q

Wed Oct 05 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: AD8; bA218C14.4 (cystatin C); cystatin 3; Cystatin-3; Cystatin-C; Cystatin3; CystatinC; epididymis secretory protein Li 2; Gamma-trace; MGC117328; Neuroendocrine basic polypeptide; OTTHUMP00000030440; OTTHUMP00000164181; OTTHUMP00000164182; OTTMUSP00000016736; Post-gamma-globulin; RP23-250M11.9

View more View less

Gene Aliases: ARMD11; CST3; CysC; HEL-S-2

View more View less

UniProt ID: (Human) P01034, (Mouse) P21460

View more View less

Entrez Gene ID: (Human) 1471, (Mouse) 13010

View more View less

Function(s)

beta-amyloid binding protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity protein binding identical protein binding peptidase inhibitor activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Cystatin C Polyclonal Antibody

Cystatin C Antibody (12245-1-AP) in ICC/IF

Product Details

12245-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!