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Invitrogen
Cystatin C Monoclonal Antibody (678920)
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Cystatin C Antibody (MA5-24309) in IHC (F)
Immunohistochemical analysis of Cystatin C in perfusion fixed frozen sections of rat brain. Samples were incubated in Cystatin C monoclonal antibody (Product # MA5-24309) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells in vasculat... View More
Product Details
MA5-24309
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
678920
Immunogen
Mouse myeloma cell line NS0-derived recombinant rat Cystatin C Gly21-Ala140
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609409
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Cystatin C, a member of the type 2 cystatin superfamily, is a potent inhibitor of cysteine proteinases, both endogenous (lysosomal cathepsins), and pathogenic. Cystatin C is a 13 kDa secreted protein which is found in high concentrations in biological fluids and is thought to be expressed by all human nucleated cells. Changes in Cystatin C have been documented in a number of cardiovascular diseases, including atherosclerosis, amyloid angiopathy and myocardial infarction. Its low molecular weight also means that Cystatin C can be used as a marker of renal failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD8; cystatin 3; Cystatin C (cysteine proteinase inhibitor); Cystatin-3; Cystatin-C; Cystatin3; CystatinC; MGC117328; OTTHUMP00000030440; OTTHUMP00000164181; OTTHUMP00000164182; OTTMUSP00000016736; RP23-250M11.9
Gene Aliases: Cst3; CYSC
UniProt ID: (Rat) P14841
Entrez Gene ID: (Rat) 25307
eye development
response to hypoxia
cell activation
apoptotic process
defense response
response to oxidative stress
brain development
salivary gland development
embryo implantation
positive regulation of cell proliferation
male gonad development
response to toxic substance
response to carbohydrate
response to inorganic substance
negative regulation of peptidase activity
negative regulation of collagen catabolic process
negative regulation of extracellular matrix disassembly
negative regulation of endopeptidase activity
response to organic cyclic compound
response to nutrient levels
response to estradiol
regulation of tissue remodeling
cellular response to oxidative stress
response to drug
circadian sleep/wake cycle, REM sleep
regulation of programmed cell death
extracellular fibril organization
positive regulation of DNA replication
negative regulation of proteolysis
response to axon injury
Sertoli cell development
negative regulation of elastin catabolic process
negative regulation of blood vessel remodeling
negative regulation of cell death
cellular response to hydrogen peroxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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