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NeoBiotechnologies
Cytochrome C Recombinant Rabbit Monoclonal Antibody (CYCS, 3128R)
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Product Details
54205-RBM6-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Amphibian,
Avian,
Dog,
Fruit fly,
Horse,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CYCS, 3128R
Immunogen
Recombinant full-length human CYCS protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG17903-PA; CG17903-PB; CRF; Cyt-c-p-PA; Cyt-c-p-PB; Cytochrome c; cytochrome c DC4; cytochrome c proximal; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; Cytochrome c-2; cytochrome c-like protein; Cytochrome c-proximal; cytochrome-c-p; Cytochrome-c-proximal; hc1
Gene Aliases: CG17903; CYC; CYCS; CYCSA; Cyct-c-p; Cyt C; cyt c-p; Cyt-c-p; Cyt-c2; cyt.c; CytC; CytC-2; Cytc-p; CYTC2; cytochrome c; DC4; dCyt.C-p; DMc01; Dmel\CG17903; Dmel_CG17903; HCS; pDMc01; THC4
UniProt ID: (Dog) P00011, (Human) P99999, (Mouse) P62897, (Rat) P62898, (Fruit fly) P84029
Entrez Gene ID: (Dog) 475258, (Human) 54205, (Horse) 100053958, (Mouse) 13063, (Rat) 25309, (Fruit fly) 34996
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial electron transport, cytochrome c to oxygen
apoptotic DNA fragmentation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to reactive oxygen species
protein dephosphorylation
mitochondrion organization
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
cellular respiration
intrinsic apoptotic signaling pathway
apoptotic process
hydrogen peroxide metabolic process
ATP synthesis coupled electron transport
oxidative phosphorylation
response to ischemia
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
positive regulation of cellular respiration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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