Rockland

Cytochrome P450 Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

600-401-HB7

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:100-1:200
-

Immunocytochemistry (ICC/IF)

15 µg/mL
-

ELISA (ELISA)

5.0 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-Cytochrome p450 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human cytochrome p450 conjugated to Keyhole Limpet Hemocyanin (KLH).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human cytochrome p450. Blast analysis the immunogen sequence shows 83.3% identity with mouse, rat, hamster, and monkey.

Target Information

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; CYP; CYP1A1; CYPIA1; cytochrome P1-450; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; Cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450; P450 form 6; P450-P1; P450form6; P450MT2; xenobiotic monooxygenase

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Gene Aliases: AHH; AHRR; CP11; CYP1; Cyp1a-1; CYP1A1; Cyp45c; Cypc45c; CYPIA1; P-450MC; P1-450; P450-C; P450DX

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UniProt ID: (Human) P04798, (Rat) P00185

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Entrez Gene ID: (Human) 1543, (Rat) 24296

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Function(s)
monooxygenase activity iron ion binding protein binding steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on diphenols and related substances as donors flavonoid 3'-monooxygenase activity oxygen binding enzyme binding heme binding demethylase activity aromatase activity vitamin D 24-hydroxylase activity catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Process(es)
response to hypoxia porphyrin-containing compound metabolic process aging cell proliferation amine metabolic process response to wounding response to virus response to nematode response to herbicide ethylene metabolic process embryo development ending in birth or egg hatching coumarin metabolic process flavonoid metabolic process response to iron(III) ion insecticide metabolic process drug metabolic process dibenzo-p-dioxin catabolic process epoxygenase P450 pathway response to food response to lipopolysaccharide response to vitamin A response to immobilization stress vitamin D metabolic process response to drug 9-cis-retinoic acid biosynthetic process camera-type eye development response to antibiotic response to arsenic-containing substance digestive tract development hydrogen peroxide biosynthetic process response to hyperoxia oxidation-reduction process maternal process involved in parturition hepatocyte differentiation demethylation cellular response to organic cyclic compound omega-hydroxylase P450 pathway positive regulation of G1/S transition of mitotic cell cycle liver development toxin metabolic process response to toxic substance response to organic substance response to organic cyclic compound dibenzo-p-dioxin metabolic process developmental process heterocycle metabolic process
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