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Invitrogen
Cytohesin 3 Polyclonal Antibody
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FIGURE: 1 / 1
Cytohesin 3 Antibody (PA5-75368) in WB
Western blot analysis of Cytohesin 3 in Lane 1: 3T3-L1 whole cell lysate (40 µg), Lane 2: H9C2 whole cell lysate (40 µg), Lane 3: A2780 whole cell lysate (40 µg), Lane 4: H1792 whole cell lysate (40 µg), Lane 5: A375 whole cell lysate (20 µg). Samples were incubated with Cytohesin 3 polyclonal antibody (Product # PA5-75368) at a dilution of 1:2000.
Product Details
PA5-75368
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 371-400 of Human GRP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719096
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARF nucleotide-binding site opener 3; CLM3; Cytohesin-3; General receptor of phosphoinositides 1; Grp1; mSec7-3; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology, Sec7 and coiled-coil domains 3; pleckstrin homology, Sec7 and coiled/coil domains 3; Protein ARNO3; rSec7-3; SEC7 homolog C
Gene Aliases: AI648983; ARNO3; CLM3; CYTH3; GRP1; PSCD3; Sec7; Sec7C
UniProt ID: (Human) O43739, (Mouse) O08967
Entrez Gene ID: (Human) 9265, (Rat) 116693, (Mouse) 19159
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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