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Progen
Cytokeratin 13 Monoclonal Antibody (Ks13.1)
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Cytokeratin 13 Antibody (61007PROGEN) in IHC (P)
Immunohistochemistry analysis of rat tongue using anti-Keratin K13 (Cat. No. 61007). IHC was performed on formalin fixed paraffin embedded sections. The samples were deparaffinized with xylol and ethanol followed by heat induced antigen retrieval with 10 mM citrate buffer. After preparation the tissue was blocked with normal serum for 20 min at RT. The primary antibody anti-Keratin K13 (Cat. No. 61007) was ... View More
Product Details
61007PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Ks13.1
Immunogen
Keratin K13 Of Mr 54,000 Purified From Human Esophagus
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
Ks 13.1 represents an excellent marker to discriminate non-cornified squamous epithelia from those of different origin. Polypeptide reacting: MW 54 000 polypeptide human keratin K13 (formerly designated cytokeratin13; with minor affinity to keratins K14, MW 50 000, and K16, MW 48 000 and also to K25, formerly designated K25irs1 from inner root sheath of hair follicle).Tumors specifically detected: several squamous cell carcinomas, e.g. cervix carcinoma; transitional cell carcinoma of the bladder; craniopharyngiomaReactivity on cultured cell lines: Cell lines from squamous cell CA, e.g. A-431 from epidermoid CA of vulva; RT 112, RT-4 of urinary bladder CA.
Target Information
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between ~40 kDa and ~68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CK-13; cytokeratin 13; Cytokeratin-13; K-13; K13; keratin 13, type I; Keratin, type I cytoskeletal 13; Keratin-13; krt13 {ECO:0000250|UniProtKB:P13646}; MGC161462; MGC3781; Type I keratin Ka13
Gene Aliases: CK13; K13; Ka13; KRT13; WSN2
UniProt ID: (Human) P13646, (Rat) Q6IFV4
Entrez Gene ID: (Human) 3860, (Rat) 287699
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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