Invitrogen

Cytokeratin 14/16 Polyclonal Antibody

1 Reference

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99310

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human KRT14(Accession P02533), corresponding to amino acid residues M1-A36.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818243

Product Specific Information

Antibody detects endogenous levels of total Cytokeratin 14/16.

Target Information

In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CK 14; CK 16; CK-14; CK-16; cytokeratin 14; cytokeratin 16; Cytokeratin-14; Cytokeratin-16; Cytokeratin14; Cytokeratin16; epidermolysis bullosa simplex, Dowling-Meara, Koebner; focal non-epidermolytic palmoplantar keratoderma; K14; K16; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 16, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 16; Keratin-14; Keratin-16; Type I keratin Ka14; type I keratin KA16

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Gene Aliases: AI324768; AI626930; CK14; CK16; EBS3; EBS4; FNEPPK; K14; K16; K1CP; Ka14; Ka16; Krt-1.14; Krt1-14; Krt1-16; KRT14; KRT16; KRT16A; NEPPK; NFJ; PC1

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UniProt ID: (Human) P02533, (Human) P08779, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q9Z2K1

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Entrez Gene ID: (Human) 3861, (Human) 3868, (Mouse) 16664, (Rat) 287701, (Mouse) 16666, (Rat) 303530

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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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