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Invitrogen
Cytokeratin 14/17 Polyclonal Antibody
Product Details
PA5-68451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human Cytokeratin 14/17 [aa 261-310].
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2688416
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39.1; CK-14; CK-17; cytokeratin 14; Cytokeratin-14; Cytokeratin-17; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; K17; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 17, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 17; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 17; Keratin-14; Keratin-17; krt17 {ECO:0000250|UniProtKB:Q04695}; Type I keratin Ka14; Type I keratin Ka17
Gene Aliases: 39.1; AI626930; CK-17; CK14; EBS3; EBS4; K14; K17; Ka14; Ka17; Krt-1.14; Krt1-14; Krt1-17; KRT14; KRT17; NFJ; PC; PC2; PCHC1
UniProt ID: (Human) P02533, (Human) Q04695, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q9QWL7, (Rat) Q6IFU8
Entrez Gene ID: (Human) 3861, (Human) 3872, (Mouse) 16664, (Rat) 287701, (Mouse) 16667, (Rat) 287702
morphogenesis of an epithelium
signal transduction
positive regulation of cell growth
hair follicle morphogenesis
keratinization
intermediate filament organization
positive regulation of translation
positive regulation of hair follicle development
aging
epithelial cell differentiation
hair cycle
intermediate filament bundle assembly
epidermis development
response to zinc ion
response to ionizing radiation
hemidesmosome assembly
intermediate filament-based process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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