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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Cytokeratin 18 Antibodies

          Proteintech

          Cytokeratin 18 Polyclonal Antibody

          97 References
          View all (157) Cytokeratin 18 antibodies

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          Cite Cytokeratin 18 Polyclonal Antibody

          • Antibody Testing Data (31)
          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 31

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          Cytokeratin 18 Antibody (10830-1-AP) in ICC/IF

          IF result of CK18 antibody (10830-1-AP, 1:50 ) with 1% PLP fixed the APical sustentacular cells of adult mouse olfactory epithelium. (Green: CK18; Blue: DAPI). Basal lamina is marked by an arrow head. By Brian Lin, Tufts University. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Cytokeratin 18 Antibody in Immunocytochemistry (ICC/IF)
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin 18 Antibody in Western Blot (WB)
          Cytokeratin 18 Antibody in Western Blot (WB)
          Cytokeratin 18 Antibody in Western Blot (WB)
          Cytokeratin 18 Antibody in Flow Cytometry (Flow)
          Cytokeratin 18 Antibody in Immunoprecipitation (IP)

          Product Details

          10830-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:4,000
          View 30 publications 30 publications

          Immunohistochemistry (IHC)

          -
          View 21 publications 21 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:1,000
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 38 publications 38 publications

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          View 2 publications 2 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 5 publications 5 publications
          Product Specifications

          Species Reactivity

          Human, Mouse

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Cytokeratin 18 Fusion Protein Ag1260 (127-430 aa encoded by BC000180)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.19 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: SHYFKIIED LRAQIFANTV DNARIVLQID NARLAADDFR VKYETELAMR QSVENDIHGL RKVIDDTNIT RLQLETEIEA LKEELLFMKK NHEEEVKGLQ AQIASSGLTV EVDAPKSQDL AKIMADIRAQ YDELARKNRE ELDKYWSQQI EESTTVVTTQ SAEVGAAETT LTELRRTVQS LEIDLDSMRN LKASLENSLR EVEARYALQM EQLNGILLHL ESELAQTRAE GQRQAQEYEA LLNIKVKLEA EIATYRRLLE DGEDFNLGDA LDSSNSMQTI QKTTTRRIVD GKVVSETNDT KVLRH (127-430 aa encoded by BC000180)

          Target Information

          Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Cell proliferation-inducing gene 46 protein; CK 18; CK-18; cytokeratin 18; Cytokeratin endo B; Cytokeratin-18; Cytokeratin18; Endo B; K 18; K18; keratin 18, type I; keratin complex 1, acidic, gene 18; Keratin D; Keratin, type I cytoskeletal 18; Keratin-18; Keratin18; KRT 18; type I cytoskeletal 18

          View more View less

          Gene Aliases: CK-18; CK18; CYK18; K18; Kerd; Krt1-18; KRT18; PIG46

          View more View less

          UniProt ID: (Human) P05783, (Mouse) P05784

          View more View less

          Entrez Gene ID: (Human) 3875, (Mouse) 16668

          View more View less

          Function(s)
          structural molecule activity protein binding poly(A) RNA binding scaffold protein binding cadherin binding involved in cell-cell adhesion
          Process(es)
          cell cycle anatomical structure morphogenesis viral process tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process intermediate filament cytoskeleton organization extrinsic apoptotic signaling pathway hepatocyte apoptotic process cell-cell adhesion
          It has to be done as per old AB suggested Products section.
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