NeoBiotechnologies

Cytokeratin, Acidic (Type I or LMW) Monoclonal Antibody (KRTL, 1077)

View all (39) Cytokeratin Pan Type I antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MSM8-1077-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

0.1-0.2 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

KRTL, 1077

Immunogen

Recombinant human KRT77 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

This antibody shows a broad species reactivity.

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40-kDa keratin intermediate filament; Acidic Cytokeratin; Cell proliferation-inducing gene 46 protein; CK-10; CK-14; CK-15; CK-16; CK-18; CK-19; CK-9; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 9; Cytokeratin-10; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-18; Cytokeratin-19; Cytokeratin-9; focal non-epidermolytic palmoplantar keratoderma; HMWCK; K10; K14; K15; K16; K18; K19; K9; keratin 10, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15, type I; keratin 16, type I; keratin 18, type I; keratin 19, type I; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 9; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; Keratin-10; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-18; Keratin-19; Keratin-9; krt10 {ECO:0000250|UniProtKB:P13645}; krt15 {ECO:0000250|UniProtKB:P19012}; krt18 {ECO:0000250|UniProtKB:P05783}; pan keratin; pankeratin; Spermatid perinuclear ring manchette protein K9; type I cytoskeletal 15; type I cytoskeletal 9; type I keratin KA10; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka19

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Gene Aliases: BCIE; BIE; CK-18; CK-9; CK10; CK14; CK15; CK16; CK19; CYK18; EBS3; EBS4; EHK; EPPK; FNEPPK; K10; K14; K15; K16; K18; K19; K1CO; K1CP; K1CS; K9; Ka10; Ka14; Ka15; Ka16; Ka19; KPP; Krt1-14; Krt1-18; Krt1-19; Krt1-9; KRT10; KRT14; KRT15; KRT16; KRT16A; KRT18; KRT19; KRT9; KRTB; NEPPK; NFJ; PC1; PIG46

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UniProt ID: (Human) P13645, (Human) P02533, (Human) P19012, (Human) P08779, (Human) P05783, (Human) P08727, (Human) P35527, (Rat) Q6IFV1, (Rat) Q6IFV3, (Rat) Q5BJY9, (Rat) Q63279, (Rat) Q8CIS9

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Entrez Gene ID: (Human) 3858, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3875, (Human) 3880, (Human) 3857, (Rat) 450225, (Rat) 287701, (Rat) 287700, (Rat) 303530, (Rat) 294853, (Rat) 360626, (Rat) 266717

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