NeoBiotechnologies

Cytokeratin, pan (Epithelial Marker) Monoclonal Antibody (SPM115, SPM116)

View all (71) Cytokeratin Pan Type I/II antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MSM2X-371-P1ABX

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

SPM115, SPM116

Immunogen

Human epidermal keratin
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK 2e; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; Cytokeratin otokeratin; Cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; epithelial keratin 1; epithelial keratin 10; epithelial keratin 2e; Epithelial keratin-1; Epithelial keratin-10; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; GK-19; Hair alpha protein; HMWCK; intermediate filament protein; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K3 keratin; K4; K5; K6A; K7; K76; K77; K8; kamp-keratin derived antimicrobial peptide; KDAMP; KERA; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 10; keratin 10 (epidermolytic hyperkeratosis); keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 13; keratin 13, type I; keratin 13-like; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 14-like; keratin 15; keratin 15, type I; keratin 16 (focal non-epidermolytic palmoplantar keratoderma); keratin 16, type I; keratin 17, type I; keratin 17-like; keratin 18; keratin 18, type I; keratin 18-like; keratin 19; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin 2p; keratin 3; keratin 3, type II; keratin 4; keratin 4, type II; keratin 5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 5-like; keratin 6 alpha; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6A-like; keratin 6B; keratin 7; keratin 7, type II; keratin 75; keratin 76, type II; keratin 77; keratin 77, type II; keratin 8; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin IV; keratin K3; keratin K6h; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; keratin-6C; Keratin-7; Keratin-76; Keratin-77; Keratin-8; KRT1; krt1 {ECO:0000250|UniProtKB:P04264}; krt10 {ECO:0000250|UniProtKB:P13645}; krt13 {ECO:0000250|UniProtKB:P13646}; krt15 {ECO:0000250|UniProtKB:P19012}; krt17 {ECO:0000250|UniProtKB:Q04695}; krt18 {ECO:0000250|UniProtKB:P05783}; KRT1B; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; krt5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; masticatory epithelia keratin 2p; mK6-alpha; otokeratin; pan Cytokeratin; pan keratin; pankeratin; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I alpha-keratin 14; type I alpha-keratin 15; type I cytoskeletal 15; type I keratin KA10; Type I keratin Ka13; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka17; Type I keratin Ka19; type II alpha keratin IIA; type II alpha-keratin IIC; type II cytoskeletal 1b; type II cytoskeletal cochleal; type II keratin Kb1; type II keratin Kb2; type II keratin Kb39; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9

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Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; BOS_19066; BOS_19067; BOS_19076; BOS_19084; BOS_19102; BOS_5003; BOS_5010; BOS_5013; BOS_5019; BOS_5035; BOS_5040; BOS_5041; CARD2; CK-10; CK-17; CK-18; CK-2e; CK-3; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; EndoA; EndoC; EPPK; FNEPPK; GK-19; HUMCYT2A; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2E; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb7; Kb9; KER1; KER10; Ker2; keratin; Kerd; KERIA; KERIB; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; KRT6B; KRT6C; KRT6D; KRT7; KRT75; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; Sak57; SCL; Tfip8; WSN1; WSN2

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UniProt ID: (Dog) Q6EIY9, (Human) P04264, (Bovine) P06394, (Dog) Q6EIZ0, (Human) P13645, (Human) P13646, (Human) P02533, (Chicken) Q6PVZ1, (Human) P19012, (Human) P08779, (Bovine) A1L595, (Human) Q04695, (Human) P05783, (Bovine) P08728, (Chicken) O93256, (Human) P08727, (Human) P35908, (Human) P12035, (Rabbit) Q29426, (Human) P19013, (Human) P13647, (Bovine) Q5XQN5, (Human) P02538, (Bovine) Q29S21, (Human) P08729, (Chicken) O93532, (Human) Q01546, (Human) Q7Z794, (Bovine) P05786, (Human) P05787, (Mouse) P04104, (Rat) Q6IMF3, (Mouse) P02535, (Mouse) P08730, (Rat) Q6IFV4, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Mouse) Q3TTY5, (Rat) Q6IG02, (Rat) Q6IG00, (Mouse) P07744, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Rat) Q6IG12, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Mouse) Q6IFZ6, (Rat) Q6IG01, (Rat) Q10758, (Mouse) P11679

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Entrez Gene ID: (Dog) 444857, (Human) 3848, (Bovine) 281888, (Rabbit) 100009029, (Dog) 491006, (Human) 3858, (Human) 3860, (Human) 3861, (Dog) 100685323, (Bovine) 404111, (Chicken) 408039, (Bovine) 507464, (Dog) 100685404, (Chicken) 408040, (Human) 3866, (Dog) 490978, (Human) 3868, (Dog) 490977, (Bovine) 281889, (Human) 3872, (Human) 3875, (Bovine) 506480, (Dog) 477601, (Bovine) 514812, (Dog) 100685481, (Chicken) 395861, (Human) 3880, (Dog) 444850, (Human) 3849, (Human) 3850, (Dog) 100683401, (Bovine) 407188, (Rabbit) 100353668, (Bovine) 527819, (Human) 3851, (Dog) 100682832, (Human) 3852, (Chicken) 407779, (Bovine) 281268, (Dog) 100687760, (Chicken) 408041, (Human) 3853, (Bovine) 614456, (Dog) 477602, (Bovine) 535697, (Human) 3855, (Chicken) 395772, (Human) 51350, (Dog) 486518, (Bovine) 407189, (Human) 374454, (Rabbit) 100348891, (Bovine) 281269, (Human) 3856, (Dog) 486513, (Mouse) 16678, (Rat) 300250, (Mouse) 16661, (Rat) 450225, (Mouse) 16663, (Rat) 287699, (Mouse) 16664, (Rat) 287701, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Mouse) 16681, (Rat) 406228, (Rat) 315323, (Mouse) 16682, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Rat) 300242, (Mouse) 110310, (Rat) 407757, (Mouse) 77055, (Mouse) 406220, (Rat) 406226, (Rat) 25626, (Mouse) 16691, (Rabbit) 100341120, (Rabbit) 100341376, (Rabbit) 100344183, (Rabbit) 100344942, (Rabbit) 100352658, (Rabbit) 100353415, (Rabbit) 100354174, (Dog) 100683333, (Dog) 486523, (Dog) 490983

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Function(s)
structural molecule activity receptor activity protein binding carbohydrate binding structural constituent of epidermis structural constituent of cytoskeleton keratin filament binding scaffold protein binding MHC class II receptor activity MHC class II protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion structural constituent of muscle protein complex binding molecular_function protein heterodimerization activity
Process(es)
epithelial cell differentiation intermediate filament cytoskeleton organization cytoskeleton organization response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development cell cycle anatomical structure morphogenesis viral process tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process extrinsic apoptotic signaling pathway hepatocyte apoptotic process cell-cell adhesion negative regulation of epithelial cell proliferation aging hair cycle intermediate filament bundle assembly morphogenesis of an epithelium inflammatory response cell proliferation epidermis development keratinocyte differentiation negative regulation of cell migration keratinization innate immune response keratinocyte migration establishment of skin barrier sebaceous gland development biological_process response to radiation tongue morphogenesis cellular response to retinoic acid hemidesmosome assembly intermediate filament-based process cellular response to calcium ion complement activation, lectin pathway negative regulation of inflammatory response response to zinc ion response to ionizing radiation response to hydrostatic pressure response to other organism regulation of translation Wnt signaling pathway wound healing intermediate filament organization positive regulation of cell growth positive regulation of translation positive regulation of hair follicle development signal transduction hair follicle morphogenesis retina homeostasis Notch signaling pathway response to oxidative stress fibrinolysis regulation of angiogenesis mitophagy in response to mitochondrial depolarization embryo development keratinocyte activation keratinocyte proliferation immune system process cell morphogenesis involved in differentiation multicellular organism development
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