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Invitrogen
DAB1 Polyclonal Antibody
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Product Details
PA1-21178
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recognizes Dab1 of 48 kDa, corresponding to amino acids 399-555 of mouse Dab1 GST fusion protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2277060
Product Specific Information
Suggested positive control for Western blot is 293 cells transfected with Dab1 HA tag and for immunoprecipitation is Dab1 knockout brain p14 lysated and Dab1 wild type brain p14 lysate. PA1-21178 detects a band of approximately 80 kDa.
Target Information
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Disabled homolog 1; mDab1; RP23-356E21.1; yotari
Gene Aliases: AI956902; C630028C02Rik; Dab1; scm; scr; scrambler; yot
UniProt ID: (Mouse) P97318
Entrez Gene ID: (Mouse) 13131
neuron migration
negative regulation of cell adhesion
small GTPase mediated signal transduction
multicellular organism development
nervous system development
central nervous system development
adult walking behavior
dendrite development
cerebellum structural organization
cerebral cortex cell migration
cerebral cortex radially oriented cell migration
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
radial glia guided migration of Purkinje cell
cell differentiation
intracellular signal transduction
positive regulation of neuron differentiation
positive regulation of protein kinase activity
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
lateral motor column neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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