Invitrogen

DAB2 Polyclonal Antibody

View all (11) DAB2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-49237

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 624-650 amino acids from the C-terminal region of mouse Dab2.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2634693

Product Specific Information

Predicted to react with rat based on sequence homology.

Target Information

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; Disabled homolog 2; DOC-2; FLJ26626; Mitogen-responsive phosphoprotein

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Gene Aliases: 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Dab2; Doc-2; Doc2; p96

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UniProt ID: (Mouse) P98078

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Entrez Gene ID: (Mouse) 13132

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Function(s)
integrin binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein C-terminus binding clathrin binding phosphatidylinositol binding AP-2 adaptor complex binding clathrin adaptor activity cargo receptor activity SMAD binding
Process(es)
cell morphogenesis involved in differentiation in utero embryonic development positive regulation of receptor recycling positive regulation of protein phosphorylation transport endocytosis receptor-mediated endocytosis pinocytosis apoptotic process activation of JUN kinase activity multicellular organism development endoderm development excretion positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of neuron projection development protein transport Wnt signaling pathway cell differentiation negative regulation of cell growth positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding positive regulation of aldosterone biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription elongation from RNA polymerase II promoter leading edge cell differentiation negative regulation of apoptotic process positive regulation of cell adhesion positive regulation of endocytosis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated clathrin coat assembly response to steroid hormone negative regulation of epithelial cell proliferation positive regulation of SMAD protein import into nucleus negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus negative regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading negative regulation of protein localization to plasma membrane positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Rho-dependent protein serine/threonine kinase activity positive regulation of clathrin-mediated endocytosis positive regulation of early endosome to late endosome transport positive regulation of aldosterone secretion positive regulation of integrin-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway
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