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Invitrogen
DAF-3 Polyclonal Antibody
Product Details
PA1-16925
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide between amino acids 700-796 of the C.elegans DAF-3 protein.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_780063
Target Information
Signals from TGF-beta superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. In Caenorhabditis elegans (C.elegans), defects in a TGF-beta-related pathway cause a reversible developmental arrest and metabolic shift at the dauer larval stage. DAF-3 transgenes interfere with dauer formation, playing a role in the nucleus. DAF-3 is unique in that it is antagonized, rather than activated, by a TGF-beta pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abnormal dauer formation protein 3; Smad protein daf-3
Gene Aliases: daf-3; F25E2.5
UniProt ID: (C. elegans) Q95QI7
Entrez Gene ID: (C. elegans) 180431
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
determination of adult lifespan
dauer larval development
regulation of pharyngeal pumping
defense response to Gram-negative bacterium
regulation of dauer larval development
positive regulation of dauer larval development
cellular response to pheromone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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