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Product Details
BS-12630R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DAP12, amino acids 31-113.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP12; DNAX-activation protein 12; KAR-associated protein; killer cell activating receptor associated protein; killer cell activating receptor-associated protein; Killer-activating receptor-associated protein; TYRO protein tyrosine kinase-binding protein
Gene Aliases: DAP12; KARAP; Ly83; PLOSL; TYROBP
UniProt ID: (Human) O43914, (Rat) Q6X9T7, (Mouse) O54885
Entrez Gene ID: (Human) 7305, (Rat) 361537, (Mouse) 22177
macrophage activation involved in immune response
neutrophil activation involved in immune response
cellular defense response
signal transduction
integrin-mediated signaling pathway
intracellular signal transduction
innate immune response
regulation of immune response
regulation of osteoclast development
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