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Bioss
DAPK1/2 Polyclonal Antibody
Product Details
BS-1713R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DAPK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 1; DAP kinase 2; DAP-kinase-related protein 1; DAP-kinase-related protein 1 beta isoform; death-associated kinase 2; Death-associated protein kinase 1; Death-associated protein kinase 2; DRP-1
Gene Aliases: D13Ucla1; DAP-Kinase; DAPK; DAPK1; DAPK2; DRP-1; DRP1
UniProt ID: (Human) P53355, (Human) Q9UIK4, (Mouse) Q80YE7, (Mouse) Q8VDF3
Entrez Gene ID: (Human) 1612, (Human) 23604, (Rat) 306722, (Mouse) 69635, (Rat) 300799, (Mouse) 13143
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
GTP binding
syntaxin-1 binding
identical protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
intracellular signal transduction
regulation of apoptotic process
anoikis
regulation of intrinsic apoptotic signaling pathway
apoptotic process
regulation of autophagy
protein autophosphorylation
positive regulation of neutrophil chemotaxis
neutrophil migration
positive regulation of eosinophil chemotaxis
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of translation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to interferon-gamma
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of N-methyl-D-aspartate selective glutamate receptor activity
phosphorylation
regulation of translation
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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