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Invitrogen
DAXX Polyclonal Antibody
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Product Details
PA5-29592
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Daxx. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547068
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (86%), Rat (88%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-C binding protein; DADB-159G18.9; Daxx; Death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40
Gene Aliases: BING2; DAP6; DAXX; EAP1
UniProt ID: (Human) Q9UER7
Entrez Gene ID: (Human) 1616
p53 binding
transcription corepressor activity
receptor signaling protein activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
protein kinase activator activity
heat shock protein binding
ubiquitin protein ligase binding
histone binding
protein N-terminus binding
androgen receptor binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of JUN kinase activity
extrinsic apoptotic signaling pathway via death domain receptors
response to metal ion
negative regulation of myotube differentiation
viral process
covalent chromatin modification
androgen receptor signaling pathway
PML body organization
regulation of protein ubiquitination
positive regulation of histone phosphorylation
positive regulation of apoptotic process
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
cellular response to tumor necrosis factor
cellular response to anoxia
positive regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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