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Proteintech
DBNL Polyclonal Antibody
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Product Details
13015-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DBNL Fusion Protein Ag4078 (131-430 aa encoded by BC031687)
Conjugate
Form
Liquid
Concentration
0.66 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KVAKASGAN YSFHKESGRF QDVGPQAPVG SVYQKTNAVS EIKRVGKDSF WAKAEKEEEN RRLEEKRRAE EAQRQLEQER RERELREAAR REQRYQEQGG EASPQRTWEQ QQEVVSRNRN EQESAVHPRE IFKQKERAMS TTSISSPQPG KLRSPFLQKQ LTQPETHFGR EPAAAISRPR ADLPAEEPAP STPPCLVQAE EEAVYEEPPE QETFYEQPPL VQQQGAGSEH IDHHIQGQGL SGQGLCARAL YDYQAADDTE ISFDPENLIT GIEVIDEGWW RGYGPDGHFG MFPANYVELI E (131-430 aa encoded by BC031687)
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Abp1; Actin-binding protein 1; Cervical mucin-associated protein; Cervical SH3P7; dbnl; dbnl {ECO:0000312|EMBL:AAH72483.1}; drebrin F; Drebrin-F; drebrin-like; Drebrin-like protein; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; src homology 3 domain-containing protein HIP-55
Gene Aliases: ABP1; CMAP; DBNL; HIP-55; HIP55; mAbp1; PP5423; SH3P7
UniProt ID: (Human) Q9UJU6, (Rat) Q9JHL4, (Mouse) Q62418
Entrez Gene ID: (Human) 28988, (Rat) 83527, (Mouse) 13169
immune system process
receptor-mediated endocytosis
synapse assembly
Rac protein signal transduction
neuron projection morphogenesis
actin filament severing
barbed-end actin filament capping
actin filament bundle assembly
podosome assembly
ruffle assembly
transport
endocytosis
adaptive immune response
activation of JUN kinase activity
cell-cell adhesion
Performance Guarantee
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