Proteintech

DBR1 Polyclonal Antibody

DBR1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

DBR1 Antibody (16019-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using DBR1 antibody 16019-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

DBR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

16019-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DBR1 Fusion Protein Ag8830 (204-544 aa encoded by BC009472)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TLGSPAASE LLEHLKPTYW FSAHLHVKFA ALMQHQAKDK GQTARATKFL ALDKCLPHRD FLQILEIEHD PSAPDYLEYD IEWLTILRAT DDLINVTGRL WNMPENNGLH ARWDYSATEE GMKEVLEKLN HDLKVPCNFS VTAACYDPSK PQTQMQLIHR INPQTTEFCA QLGIIDINVR LQKSKEEHHV CGEYEEQDDV ESNDSGEDQS EYNTDTSALS SINPDEIMLD EEEDEDSIVS AHSGMNTPSV EPSDQASEFS ASFSDVRILP GSMIVSSDDT VDSTIDREGK PGGTVESGNG EDLTKVPLKR LSDEHEPEQR KKIKRRNQAI YAAVDDDDDD AA (204-544 aa encoded by BC009472)

Target Information

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Role of DBR1 as a Candidate Prognosis Biomarker in Esophageal Squamous Cell Carcinoma.

Technology in cancer research & treatment

Xu X,Yang X,Liu X,Bi Y,Kong P,Wang Y,Cheng X,Xi Y

Mon May 02 00:00:00 UTC 2022

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Cell

Zhang SY,Clark NE,Freije CA,Pauwels E,Taggart AJ,Okada S,Mandel H,Garcia P,Ciancanelli MJ,Biran A,Lafaille FG,Tsumura M,Cobat A,Luo J,Volpi S,Zimmer B,Sakata S,Dinis A,Ohara O,Garcia Reino EJ,Dobbs K,Hasek M,Holloway SP,McCammon K,Hussong SA,DeRosa N,Van Skike CE,Katolik A,Lorenzo L,Hyodo M,Faria E,Halwani R,Fukuhara R,Smith GA,Galvan V,Damha MJ,Al-Muhsen S,Itan Y,Boeke JD,Notarangelo LD,Studer L,Kobayashi M,Diogo L,Fairbrother WG,Abel L,Rosenberg BR,Hart PJ,Etzioni A,Casanova JL

Thu Feb 22 00:00:00 UTC 2018

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Cell

Thu Feb 22 00:00:00 UTC 2018

Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.

International journal of molecular sciences

Masaki S,Yoshimoto R,Kaida D,Hata A,Satoh T,Ohno M,Kataoka N

Mon Feb 09 00:00:00 UTC 2015

Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.

International journal of molecular sciences

Masaki S,Yoshimoto R,Kaida D,Hata A,Satoh T,Ohno M,Kataoka N

Mon Feb 09 00:00:00 UTC 2015

Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.

International journal of molecular sciences

Masaki S,Yoshimoto R,Kaida D,Hata A,Satoh T,Ohno M,Kataoka N

Mon Feb 09 00:00:00 UTC 2015

Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.

International journal of molecular sciences

Masaki S,Yoshimoto R,Kaida D,Hata A,Satoh T,Ohno M,Kataoka N

Mon Feb 09 00:00:00 UTC 2015

Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.

PloS one

Hett A,West S

Fri Jun 12 00:00:00 UTC 2015

Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.

PloS one

Hett A,West S

Fri Jun 12 00:00:00 UTC 2015

Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition.

Molecular & cellular proteomics : MCP

Syred HM,Welburn J,Rappsilber J,Ohkura H

Fri Nov 01 00:00:00 UTC 2013

Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition.

Molecular & cellular proteomics : MCP

Syred HM,Welburn J,Rappsilber J,Ohkura H

Fri Nov 01 00:00:00 UTC 2013

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.

Nature genetics

Armakola M,Higgins MJ,Figley MD,Barmada SJ,Scarborough EA,Diaz Z,Fang X,Shorter J,Krogan NJ,Finkbeiner S,Farese RV,Gitler AD

Sat Dec 01 00:00:00 UTC 2012

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.

Nature genetics

Armakola M,Higgins MJ,Figley MD,Barmada SJ,Scarborough EA,Diaz Z,Fang X,Shorter J,Krogan NJ,Finkbeiner S,Farese RV,Gitler AD

Sat Dec 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: debranching enzyme homolog 1; Lariat debranching enzyme; RNA lariat debranching enzyme

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Gene Aliases: DBR1

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UniProt ID: (Human) Q9UK59

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Entrez Gene ID: (Human) 51163

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Function(s)

RNA lariat debranching enzyme activity poly(A) RNA binding metal ion binding

Process(es)

RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA phosphodiester bond hydrolysis, endonucleolytic

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DBR1 Polyclonal Antibody

DBR1 Antibody (16019-1-AP) in ICC/IF

Product Details

16019-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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