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Product Details
MA1-40070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgM
Class
Monoclonal
Type
Antibody
Clone
ER-TR9
Immunogen
Murine SIGN-R1.
Conjugate
Form
Liquid
Concentration
Conc. not determined
Purification
purified
Storage buffer
cell culture media
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2074441
Product Specific Information
MA1-40070 detects SIGN-R1 from mouse samples.
MA1-40070 has been successfully used in flow cytometry, functional assays, immunohistochemistry (paraffin) and immunohistochemistry (frozen) applications.
The MA1-40070 immunogen is mouse SIGN-R1.
Target Information
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD209; CD209 antigen-like protein A; DC-SIGN; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC129965; MGC130443
Gene Aliases: CD209; Cd209a; CDSIGN; CIRE; DC-SIGN; DC-SIGN1; Dcsign; SIGN-R1; SIGNR5
UniProt ID: (Mouse) Q91ZX1
Entrez Gene ID: (Mouse) 170786
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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