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Proteintech
DCP1A Polyclonal Antibody
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Product Details
22373-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DCP1A Fusion Protein Ag18027 (1-350 aa encoded by BC007439)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically react with the 70 kDa DCP1A protein.
Immunogen sequence: MEALSRAGQ EMSLAALKQH DPYITSIADL TGQVALYTFC PKANQWEKTD IEGTLFVYRR SASPYHGFTI VNRLNMHNLV EPVNKDLEFQ LHEPFLLYRN ASLSIYSIWF YDKNDCHRIA KLMADVVEEE TRRSQQAARD KQSPSQANGC SDHRPIDILE MLSRAKDEYE RNQMGDSNIS SPGLQPSTQL SNLGSTETLE EMPSGSQDKS APSGHKHLTV EELFGTSLPK EQPAVVGLDS EEMERLPGDA SQKEPNSFLP FPFEQLGGAP QSETLGVPSA AHHSVQPEIT TPVLITPASI TQSNEKHAPT YTIPLSPVLS PTLPAEAPTA QVPPSLPRNS TMMQAVKTTP R (1-350 aa encoded by BC007439)
Target Information
Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DCP1 decapping enzyme homolog A; DCP1 decapping enzyme-like protein A; decapping enzyme; decapping enzyme hDcp1a; FLJ21691; MAD homolog 4 interacting transcription coactivator 1; MAD homolog 4-interacting transcription coactivator 1; mRNA-decapping enzyme 1A; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; test2; Transcription factor SMIF
Gene Aliases: 1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; DCP1A; HSA275986; Mitc1; Nbla00360; RGD1561298; SMAD4IP1; SMIF
UniProt ID: (Human) Q9NPI6, (Mouse) Q91YD3
Entrez Gene ID: (Human) 55802, (Rat) 361109, (Mouse) 75901
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
deadenylation-dependent decapping of nuclear-transcribed mRNA
deadenylation-independent decapping of nuclear-transcribed mRNA
positive regulation of catalytic activity
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
protein localization to cytoplasmic stress granule
regulation of catalytic activity
transforming growth factor beta receptor signaling pathway
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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