Proteintech

DCTN6 Polyclonal Antibody

DCTN6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DCTN6 Antibody (16947-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 16947-1-AP) (DCTN6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

DCTN6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16947-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DCTN6 Fusion Protein Ag10561 (1-190 aa encoded by BC013175)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEKTQKSV KIAPGAVVCV ESEIRGDVTI GPRTVIHPKA RIIAEAGPIV IGEGNLIEEQ ALIINAYPDN ITPDTEDPEP KPMIIGTNNV FEVGCYSQAM KMGDNNVIES KAYVGRNVIL TSGCIIGACC NLNTFEVIPE NTVIYGADCL RRVQTERPQP QTLQLDFLMK ILPNYHHLKK TMKGSSTPVK N (1-190 aa encoded by BC013175)

Target Information

The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.

Neurobiology of aging

Sharoar MG,Zhou J,Benoit M,He W,Yan R

Mon Nov 01 00:00:00 UTC 2021

Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.

Neurobiology of aging

Sharoar MG,Zhou J,Benoit M,He W,Yan R

Mon Nov 01 00:00:00 UTC 2021

Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.

Neurobiology of aging

Sharoar MG,Zhou J,Benoit M,He W,Yan R

Mon Nov 01 00:00:00 UTC 2021

An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation.

Current biology : CB

di Pietro F,Valon L,Li Y,Goïame R,Genovesio A,Morin X

Mon Aug 21 00:00:00 UTC 2017

An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation.

Current biology : CB

di Pietro F,Valon L,Li Y,Goïame R,Genovesio A,Morin X

Mon Aug 21 00:00:00 UTC 2017

Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles.

Molecular biology of the cell

Cavolo SL,Zhou C,Ketcham SA,Suzuki MM,Ukalovic K,Silverman MA,Schroer TA,Levitan ES

Wed Jul 15 00:00:00 UTC 2015

Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles.

Molecular biology of the cell

Cavolo SL,Zhou C,Ketcham SA,Suzuki MM,Ukalovic K,Silverman MA,Schroer TA,Levitan ES

Wed Jul 15 00:00:00 UTC 2015

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

The EMBO journal

Yeh TY,Kowalska AK,Scipioni BR,Cheong FK,Zheng M,Derewenda U,Derewenda ZS,Schroer TA

Wed Apr 03 00:00:00 UTC 2013

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

The EMBO journal

Yeh TY,Kowalska AK,Scipioni BR,Cheong FK,Zheng M,Derewenda U,Derewenda ZS,Schroer TA

Wed Apr 03 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: dynactin 6; Dynactin subunit 6; Dynactin subunit p27; novel RGD-containing protein; p27 dynactin subunit; Protein WS-3; RGD containing protein

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Gene Aliases: AU044699; DCTN6; p27; WS-3; WS3

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UniProt ID: (Human) O00399, (Mouse) Q9WUB4

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Entrez Gene ID: (Human) 10671, (Mouse) 22428, (Rat) 290798

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Function(s)

catalytic activity dynein binding

Process(es)

mitochondrion organization mitotic spindle organization lipid biosynthetic process ER to Golgi vesicle-mediated transport antigen processing and presentation of exogenous peptide antigen via MHC class II

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DCTN6 Polyclonal Antibody

DCTN6 Antibody (16947-1-AP) in IHC (P)

Product Details

16947-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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