Proteintech

DCUN1D1 Polyclonal Antibody

DCUN1D1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DCUN1D1 Antibody (10965-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 10965-1-AP ( DCUN1D1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

10965-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DCUN1D1 Fusion Protein Ag1440 (1-259 aa encoded by BC009478)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNKLKSSQK DKVRQFMIFT QSSEKTAVSC LSQNDWKLDV ATDNFFQNPE LYIRESVKGS LDRKKLEQLY NRYKDPQDEN KIGIDGIQQF CDDLALDPAS ISVLIIAWKF RAATQCEFSK QEFMDGMTEL GCDSIEKLKA QIPKMEQELK EPGRFKDFYQ FTFNFAKNPG QKGLDLEMAI AYWNLVLNGR FKFLDLWNKF LLEHHKRSIP KDTWNLLLDF STMIADDMSN YDEEGAWPVL IDDFVEFARP QIAGTKSTTV (1-259 aa encoded by BC009478)

Target Information

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A male germ-cell-specific ribosome controls male fertility.

Nature

Li H,Huo Y,He X,Yao L,Zhang H,Cui Y,Xiao H,Xie W,Zhang D,Wang Y,Zhang S,Tu H,Cheng Y,Guo Y,Cao X,Zhu Y,Jiang T,Guo X,Qin Y,Sha J

Thu Dec 01 00:00:00 UTC 2022

Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zhou W,Dong G,Gao G,He Z,Xu J,Aziz S,Ma L,Zhao W

Mon Aug 01 00:00:00 UTC 2022

Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zhou W,Dong G,Gao G,He Z,Xu J,Aziz S,Ma L,Zhao W

Mon Aug 01 00:00:00 UTC 2022

Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zhou W,Dong G,Gao G,He Z,Xu J,Aziz S,Ma L,Zhao W

Mon Aug 01 00:00:00 UTC 2022

Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zhou W,Dong G,Gao G,He Z,Xu J,Aziz S,Ma L,Zhao W

Mon Aug 01 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: DCN1, defective in cullin neddylation 1, domain containing 1; DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; RP42 homolog; squamous cell carcinoma related oncogene; Squamous cell carcinoma-related oncogene; testis derived transcript 3; Testis-specific protein 3

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Gene Aliases: DCN1; DCNL1; DCUN1D1; DCUN1L1; pTes3; RP42; SCCRO; SCRO; Tes3

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UniProt ID: (Human) Q96GG9, (Mouse) Q9QZ73

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Entrez Gene ID: (Human) 54165, (Rat) 310324, (Mouse) 114893

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Function(s)

protein binding ubiquitin conjugating enzyme binding ubiquitin-like protein binding cullin family protein binding

Process(es)

biological_process protein neddylation positive regulation of ubiquitin-protein transferase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DCUN1D1 Polyclonal Antibody

DCUN1D1 Antibody (10965-1-AP) in IHC (P)

Product Details

10965-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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