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DCX Polyclonal Antibody

DCX Antibody in Immunocytochemistry (ICC/IF)

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DCX Antibody (13925-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed SH-SY5Y cells using (Product # 13925-1-AP) (DCX antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

DCX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

13925-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 13 publications 13 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DCX Fusion Protein Ag4945 (1-360 aa encoded by BC027925)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Anti-DCX antibodies are widely used for detection of neurogenesis. It is also a common neuron marker since its expression is specific to neurons.

Immunogen sequence: MELDFGHFD ERDKTSRNMR GSRMNGLPSP THSAHCSFYR TRTLQALSNE KKAKKVRFYR NGDRYFKGIV YAVSSDRFRS FDALLADLTR SLSDNINLPQ GVRYIYTIDG SRKIGSMDEL EEGESYVCSS DNFFKKVEYT KNVNPNWSVN VKTSANMKAP QSLASSNSAQ ARENKDFVRP KLVTIIRSGV KPRKAVRVLL NKKTAHSFEQ VLTDITEAIK LETGVVKKLY TLDGKQVTCL HDFFGDDDVF IACGPEKFRY AQDDFSLDEN ECRVMKGNPS ATAGPKASPT PQKTSAKSPG PMRRSKSPAD SANGTSSSQL STPKSKQSPI STPTSPGSLR KHKDLYLPLS LDDSDSLGDS M (1-360 aa encoded by BC027925)

Target Information

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Thu May 11 00:00:00 UTC 2023

miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.

Neuroscience

Deng LJ,Wu D,Yang XF,Li T

Mon Aug 21 00:00:00 UTC 2023

miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.

Neuroscience

Deng LJ,Wu D,Yang XF,Li T

Mon Aug 21 00:00:00 UTC 2023

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells.

PLoS pathogens

Wang XZ,Wen L,Zhou YP,Huang SN,Yang B,Cheng S,Zeng WB,Mei MJ,Sun JY,Jiang X,Cheng H,Luo MH

Wed Feb 01 00:00:00 UTC 2023

Adult Neurogenesis Is Altered by Circadian Phase Shifts and the Duper Mutation in Female Syrian Hamsters.

eNeuro

Bahiru MS,Bittman EL

Wed Mar 01 00:00:00 UTC 2023

A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats.

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Fang XY,Zhao DW,Zhang C,Ge HF,Zhang XY,Zhao FC,Jiang YB,Feng H,Hu R

Tue Nov 01 00:00:00 UTC 2022

Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.

Experimental neurology

Liu MX,Luo L,Fu JH,He JY,Chen MY,He ZJ,Jia J

Tue Mar 01 00:00:00 UTC 2022

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology.

Journal of neuroinflammation

Liu S,Fan M,Xu JX,Yang LJ,Qi CC,Xia QR,Ge JF

Mon Feb 07 00:00:00 UTC 2022

Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling.

Brain, behavior, and immunity

Zhang Y,Fan Q,Hou Y,Zhang X,Yin Z,Cai X,Wei W,Wang J,He D,Wang G,Yuan Y,Hao H,Zheng X

Sun May 01 00:00:00 UTC 2022

Conditional deletion of MAD2B in forebrain neurons enhances hippocampus-dependent learning and memory in mice.

Frontiers in cellular neuroscience

Cheng L,Su Y,Zhi K,Xie Y,Zhang C,Meng X

Tue Oct 11 00:00:00 UTC 2022

FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.

International journal of molecular sciences

Wang J,Zhai HR,Ma SF,Shi HZ,Zhang WJ,Yun Q,Liu WJ,Liu ZZ,Zhang WN

Tue Nov 29 00:00:00 UTC 2022

FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.

International journal of molecular sciences

Wang J,Zhai HR,Ma SF,Shi HZ,Zhang WJ,Yun Q,Liu WJ,Liu ZZ,Zhang WN

Tue Nov 29 00:00:00 UTC 2022

Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury.

Neuroscience

Zhang Z,Li J,Wang B,Hou C,Liu Q,Wang W,Zhao Y,Yin Q,Yang S,Zhang H,Yang X

Mon Aug 01 00:00:00 UTC 2022

Nde1 is required for heterochromatin compaction and stability in neocortical neurons.

iScience

Chomiak AA,Guo Y,Kopsidas CA,McDaniel DP,Lowe CC,Pan H,Zhou X,Zhou Q,Doughty ML,Feng Y

Fri Jun 17 00:00:00 UTC 2022

Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke.

Neural regeneration research

Zhong J,Li RW,Wang J,Wang Y,Ge HF,Xian JS,Feng H,Tan L

Mon Feb 01 00:00:00 UTC 2021

Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain.

Nature communications

Zhang M,Wang J,Zhang K,Lu G,Liu Y,Ren K,Wang W,Xin D,Xu L,Mao H,Xing J,Gao X,Jin W,Berry K,Mikoshiba K,Wu S,Lu QR,Zhao X

Tue Aug 24 00:00:00 UTC 2021

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ni GX,Liang C,Wang J,Duan CQ,Wang P,Wang YL

Thu Oct 01 00:00:00 UTC 2020

Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.

Biochemical and biophysical research communications

Asamitsu S,Imai Y,Yabuki Y,Ikenoshita S,Takeuchi M,Kashiwagi H,Tanoue Y,Fukuda T,Shioda N

Thu Oct 08 00:00:00 UTC 2020

G protein-coupled estrogen receptor 1 negatively regulates the proliferation of mouse-derived neural stem/progenitor cells via extracellular signal-regulated kinase pathway.

Brain research

Zhong J,Ge HF,Zhang C,Chen JY,Li HH,Fang XY,Tan L,Liu X,Jia ZC,Feng H,Hu R

Mon Jul 01 00:00:00 UTC 2019

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Frontiers in cellular neuroscience

Xu L,Xing Q,Huang T,Zhou J,Liu T,Cui Y,Cheng T,Wang Y,Zhou X,Yang B,Yang GL,Zhang J,Zang X,Ma S,Guan F

Wed Sep 30 00:00:00 UTC 2020

HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway.

Frontiers in cellular neuroscience

Xu L,Xing Q,Huang T,Zhou J,Liu T,Cui Y,Cheng T,Wang Y,Zhou X,Yang B,Yang GL,Zhang J,Zang X,Ma S,Guan F

Wed Sep 30 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: doublecortex; Doublin; Lis-X; LIS-XD; Lissencephalin-X; lissencephaly, X-linked (doublecortin); Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316

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Gene Aliases: DBCN; Dbct; DC; Dcn; DCX; LISX; SCLH; XLIS

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UniProt ID: (Human) A9Z1V8, (Mouse) O88809

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Entrez Gene ID: (Human) 1641, (Mouse) 13193

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Function(s)

calmodulin-dependent protein kinase activity protein binding calmodulin binding microtubule binding calcium-dependent protein serine/threonine kinase activity protein kinase binding

Process(es)

neuron migration multicellular organism development nervous system development brain development peptidyl-serine phosphorylation central nervous system projection neuron axonogenesis cell differentiation intracellular signal transduction protein autophosphorylation axon extension dendrite morphogenesis central nervous system development hippocampus development layer formation in cerebral cortex pyramidal neuron development response to electrical stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DCX Polyclonal Antibody

DCX Antibody (13925-1-AP) in ICC/IF

Product Details

13925-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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