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Immunogen sequence: RNKKDRDRDK DGHRRDKDRK RSSLSPGRGK DFKSRKDRDS KKDEEDEHGD KKPKAQPLSL EELLAKKKAE EEAEAKPKFL SKAEREAEAL KRRQQ
PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 100 kDa U5 snRNP-specific protein; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; DEAD box protein 23; Probable ATP-dependent RNA helicase DDX23; PRP28 homolog; PRP28 homolog, yeast; PRP28p homolog; U5 snRNP 100 kD protein; U5-100kD
Gene Aliases: DDX23; prp28; PRPF28; SNRNP100; U5-100K; U5-100KD
UniProt ID: (Human) Q9BUQ8
Entrez Gene ID: (Human) 9416
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