Abnova

DDX3X Polyclonal Antibody, MaxPab™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00001654-B01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DDX3X (NP_001347, 1 a.a. approximately 662 a.a) full-length human protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW GN

Target Information

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent RNA helicase DDX3X; CAP-Rf; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; Helicase-like protein 2; HLP2

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Gene Aliases: CAP-Rf; DBX; DDX14; DDX3; DDX3X; HLP2; MRX102

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UniProt ID: (Human) O00571

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Entrez Gene ID: (Human) 1654

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Function(s)
DNA binding RNA binding GTPase activity ATP-dependent DNA helicase activity ATP-dependent RNA helicase activity protein binding ATP binding transcription factor binding poly(A) binding eukaryotic initiation factor 4E binding ATPase activity nucleoside-triphosphatase activity translation initiation factor binding RNA stem-loop binding ribosomal small subunit binding CTPase activity poly(A) RNA binding mRNA 5'-UTR binding cadherin binding involved in cell-cell adhesion
Process(es)
transcription, DNA-templated chromosome segregation extrinsic apoptotic signaling pathway via death domain receptors response to virus RNA secondary structure unwinding positive regulation of gene expression Wnt signaling pathway negative regulation of translation positive regulation of cell growth negative regulation of cell growth negative regulation of protein complex assembly DNA duplex unwinding positive regulation of interferon-beta production stress granule assembly intracellular signal transduction mature ribosome assembly positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of viral genome replication innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation cellular response to arsenic-containing substance cellular response to osmotic stress positive regulation of chemokine (C-C motif) ligand 5 production intrinsic apoptotic signaling pathway cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle protein localization to cytoplasmic stress granule negative regulation of intrinsic apoptotic signaling pathway
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