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Product Details
26385-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DDX5 Fusion Protein Ag24821 (434-614 aa encoded by NM_004396)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RSTKTGTAY TFFTPNNIKQ VSDLISVLRE ANQAINPKLL QLVEDRGSGR SRGRGGMKDD RRDRYSAGKR GGFNTFRDRE NYDRGYSSLL KRDFGAKTQN GVYSAANYTN GSFGSNFVSA GIQTSFRTGN PTGTYQNGYD STQQYGSNVP NMHNGMNQQA YAYPATAAAP MIGYPMPTGY SQ (434-614 aa encoded by NM_004396)
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase DDX5; DEAD (Asp-Glu-Ala-Asp) box helicase 5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD box protein 5; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); DKFZp434E109; DKFZp686J01190; MGC118083; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; RP23-247J12.4
Gene Aliases: DDX5; G17P1; HELR; HLR1; HUMP68; p68
UniProt ID: (Human) P17844
Entrez Gene ID: (Human) 1655
negative regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
mRNA transcription
RNA secondary structure unwinding
cell growth
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of DNA damage response, signal transduction by p53 class mediator
regulation of viral genome replication
regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of androgen receptor signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of skeletal muscle cell differentiation
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