Proteintech

DDX5/p68 Polyclonal Antibody

DDX5/p68 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

DDX5/p68 Antibody (10804-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10804-1-AP ( DDX5,p68 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

10804-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DDX5,p68 Fusion Protein Ag1237 (265-614 aa encoded by BC016027)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IVDQIRPDR QTLMWSATWP KEVRQLAEDF LKDYIHINIG ALELSANHNI LQIVDVCHDV EKDEKLIRLM EEIMSEKENK TIVFVETKRR CDELTRKMRR DGWPAMGIHG DKSQQERDWV LNEFKHGKAP ILIATDVASR GLDVEDVKFV INYDYPNSSE DYIHRIGRTA RSTKTGTAYT FFTPNNIKQV SDLISVLREA NQAINPKLLQ LVEDRGSGRS RGRGGMKDDR RDRYSAGKRG GFNTFRDREN YDRGYSSLLK RDFGAKTQNG VYSAANYTNG SFGSNFVSAG IQTSFRTGNP TGTYQNGYDS TQQYGSNVPN MHNGMNQQAY AYPATAAAPM IGYPMPTGYS Q (265-614 aa encoded by BC016027)

Target Information

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.

Drug design, development and therapy

Yin X,Yang Q,Li H,Kang Y,Li Z

Fri Feb 10 00:00:00 UTC 2023

Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.

Drug design, development and therapy

Yin X,Yang Q,Li H,Kang Y,Li Z

Fri Feb 10 00:00:00 UTC 2023

Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.

Drug design, development and therapy

Yin X,Yang Q,Li H,Kang Y,Li Z

Fri Feb 10 00:00:00 UTC 2023

Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.

Drug design, development and therapy

Yin X,Yang Q,Li H,Kang Y,Li Z

Fri Feb 10 00:00:00 UTC 2023

Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.

International immunopharmacology

Zheng J,Wang S,Zhang T,Li H,Zhu M,Wei X,Ge Y,Yang X,Zhang S,Xu H,Duan Y,Liu L,Chen Y

Sat Jul 01 00:00:00 UTC 2023

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.

Cell death discovery

Qiu P,Jie Y,Ma C,Chen H,Qin Y,Tu K,Wang L,Zhang Z

Tue Jun 07 00:00:00 UTC 2022

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.

Cell death discovery

Qiu P,Jie Y,Ma C,Chen H,Qin Y,Tu K,Wang L,Zhang Z

Tue Jun 07 00:00:00 UTC 2022

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Microbiology spectrum

Zhao L,Zhao Y,Liu Q,Huang J,Lu Y,Ping J

Wed Jun 29 00:00:00 UTC 2022

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Microbiology spectrum

Zhao L,Zhao Y,Liu Q,Huang J,Lu Y,Ping J

Wed Jun 29 00:00:00 UTC 2022

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Microbiology spectrum

Zhao L,Zhao Y,Liu Q,Huang J,Lu Y,Ping J

Wed Jun 29 00:00:00 UTC 2022

Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.

Data in brief

Okada N,Oshima K,Iwasaki Y,Maruko A,Matsumura K,Iioka E,Vu TD,Fujitsuka N,Nishi A,Sugiyama A,Nishiyama M,Kaneko A,Mizoguchi K,Yamamoto M,Nishimura S

Wed Jun 01 00:00:00 UTC 2022

Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.

Nature aging

Cai D,Han JJ

Sat May 01 00:00:00 UTC 2021

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.

Gene

Okada N,Oshima K,Iwasaki Y,Maruko A,Matsumura K,Iioka E,Vu TD,Fujitsuka N,Nishi A,Sugiyama A,Nishiyama M,Kaneko A,Mizoguchi K,Yamamoto M,Nishimura S

Fri Aug 20 00:00:00 UTC 2021

Modulation of PDCD1 exon 3 splicing.

RNA biology

Sun J,Bai J,Jiang T,Gao Y,Hua Y

Sun Dec 01 00:00:00 UTC 2019

Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Zhou Q,Xie F,Zhou B,Wang J,Wu B,Li L,Kang Y,Dai R,Jiang Y

Wed May 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: ATP-dependent RNA helicase DDX5; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5; ddx5 gene protein; DEAD (Asp-Glu-Ala-Asp) box helicase 5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box protein 5; DEAD box RNA helicase DEAD1; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); DKFZp434E109; DKFZp686J01190; mDEAD1; MGC118083; p68 RNA helicase; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; RP23-247J12.4

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Gene Aliases: 2600009A06Rik; DDX5; G17P1; HELR; HLR1; HUMP68; p68

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UniProt ID: (Human) P17844

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Entrez Gene ID: (Human) 1655, (Mouse) 13207, (Rat) 287765

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Function(s)

transcription coactivator activity RNA helicase activity ATP-dependent RNA helicase activity protein binding calmodulin binding ATP binding enzyme binding estrogen receptor binding pre-mRNA binding poly(A) RNA binding calcium-dependent protein binding androgen receptor binding nucleotide binding nucleic acid binding transcription cofactor activity RNA binding helicase activity hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome mRNA transcription RNA secondary structure unwinding cell growth positive regulation of intracellular estrogen receptor signaling pathway positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of viral genome replication regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter rhythmic process regulation of androgen receptor signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator regulation of skeletal muscle cell differentiation in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated mRNA processing circadian rhythm RNA splicing positive regulation of transcription, DNA-templated metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DDX5/p68 Polyclonal Antibody

DDX5/p68 Antibody (10804-1-AP) in IHC (P)

Product Details

10804-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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