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Invitrogen
DEDD2 Polyclonal Antibody
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DEDD2 Antibody (PA5-72905) in IHC (P)
Immunohistochemical analysis of DEDD2 in immersion fixed paraffin-embedded sections of human spleen. Samples were incubated in DEDD2 polyclonal antibody (Product # PA5-72905) using a dilution of 1:500 for 1 hour at room temperature followed by the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized t... View More
Product Details
PA5-72905
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 175-193 of human DEDD2/Flame-3 was used as immunogen; GenBank no. gi 19923050 ref NP_579874.1
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718759
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DED-containing protein FLAME-3; DNA-binding death effector domain-containing protein 2; FADD-like anti-apoptotic molecule 3
Gene Aliases: DEDD2; FLAME-3; FLAME3; PSEC0004
UniProt ID: (Human) Q8WXF8
Entrez Gene ID: (Human) 162989
transcription, DNA-templated
RNA processing
extrinsic apoptotic signaling pathway via death domain receptors
rRNA catabolic process
cellular homeostasis
apoptotic nuclear changes
intracellular signal transduction
negative regulation of transcription, DNA-templated
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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