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Proteintech
DENND1A Polyclonal Antibody
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Product Details
25658-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DENND1A Fusion Protein Ag22547 (451-559 aa encoded by BC039703)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody (25658-1-AP) can recognize all isoforms at 112 kDa and 52-64 kDa.
Immunogen sequence: QKDIAENGC APTPEEQLPK TAPSPLVEAK DPKLREDRRP ITVHFGQVRP PRPHVVKRPK SNIAVEGRRT SVPSPEQNTI ATPATLHILQ KSITHFAAKF PTRGWTSSSH (451-559 aa encoded by BC039703)
Target Information
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2). Thus, connecdenns link RAB35 activation with the clathrin machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Connecdenn; Connecdenn 1; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; Protein FAM31A; RP11-230L22.3
Gene Aliases: DENND1A; FAM31A; KIAA1608
UniProt ID: (Human) Q8TEH3
Entrez Gene ID: (Human) 57706
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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