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Invitrogen
DENND1B Polyclonal Antibody
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Product Details
PA5-21824
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DENND1B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153211
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASL1/9AS1-1 fusion; Connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; family with sequence similarity 31, member B; Protein FAM31B; RP11-53I24.2
Gene Aliases: 4632404N19Rik; 4930467M19Rik; 6820401H01Rik; C1ORF18; C1orf218; DENND1B; F730008N07Rik; FAM31B
UniProt ID: (Human) Q6P3S1, (Mouse) Q3U1T9
Entrez Gene ID: (Human) 163486, (Mouse) 329260
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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