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Invitrogen
DENND1B Polyclonal Antibody
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DENND1B Antibody (PA5-23885) in IHC (P)
Immunohistochemistry analysis of DENND1B in formalin fixed and paraffin embedded human lymph tissue. Samples were incubated with DENND1B polyclonal antibody (Product # PA5-23885) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-23885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human DENND1B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2541385
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; family with sequence similarity 31, member B; Protein FAM31B; RP11-53I24.2
Gene Aliases: C1ORF18; C1orf218; DENND1B; FAM31B
UniProt ID: (Human) Q6P3S1
Entrez Gene ID: (Human) 163486
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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