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Proteintech
DENND3 Polyclonal Antibody
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Product Details
24414-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DENND3 Fusion Protein Ag19859 (1-360 aa encoded by BC133023)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRSLRKKRE KPRPEQWKGL PGPPRAPEPE DVAVPGGVDL LTLPQLCFPG GVCVATEPKE DCVHFLVLTD VCGNRTYGVV AQYYRPLHDE YCFYNGKTHR ECPGCFVPFA VCVVSRFPYY NSLKDCLSCL LALLKPCKDF EVDSHIKDFA AKLSLIPSPP PGPLHLVFNM KSLQIVLPAR ADPESPILDL DLHLPLLCFR PEKVLQILTC ILTEQRIVFF SSDWALLTLV TECFMAYLYP LQWQHPFVPI LSDQMLDFVM APTSFLMGCH LDHFEEVSKE ADGLVLINID HGSITYSKST DDNVDIPDVP LLAAQTFIQR DVKNHLNYEH RVFNSEEFLK TRAPGDHQFY KQVLDTYMFH S (1-360 aa encoded by BC133023)
Target Information
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DENN domain-containing protein 3; DENN/MADD domain containing 3
Gene Aliases: AI447457; DENND3; E030003N15Rik; KIAA0870
UniProt ID: (Human) A2RUS2, (Mouse) A2RT67
Entrez Gene ID: (Human) 22898, (Mouse) 105841
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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