Proteintech

DFNA5 Polyclonal Antibody

DFNA5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 12

DFNA5 Antibody (13075-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse small intestine tissue slide using 13075-1-AP (DFNA5 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

13075-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DFNA5 Fusion Protein Ag3746 (111-460 aa encoded by BC019689)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SQSSFGTLR KQEVDLQQLI RDSAERTINL RNPVLQQVLE GRNEVLCVLT QKITTMQKCV ISEHMQVEEK CGGIVGIQTK TVQVSATEDG NVTKDSNVVL EIPAATTIAY GVIELYVKLD GQFEFCLLRG KQGGFENKKR IDSVYLDPLV FREFAFIDMP DAAHGISSQD GPLSVLKQAT LLLERNFHPF AELPEPQQTA LSDIFQAVLF DDELLMVLEP VCDDLVSGLS PTVAVLGELK PRQQQDLVAF LQLVGCSLQG GCPGPEDAGS KQLFMTAYFL VSALAEMPDS AAALLGTCCK LQIIPTLCHL LRALSDDGVS DLEDPTLTPL KDTERFGIVQ RLFASADISL (111-460 aa encoded by BC019689)

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas as two alternatively spliced isoforms, designated short and long. Defects in the gene encoding DFNA5 are the cause of non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of sensorineural hearing loss that results from damage to one of various structures that receive sound information in the brain. The gene encoding DFNA5 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.

Cell death & disease

Chen Z,Li Y,Yuan Y,Lai K,Ye K,Lin Y,Lan R,Chen H,Xu Y

Thu May 11 00:00:00 UTC 2023

Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor.

Cellular signalling

Yang L,Liu T,Zhuo Y,Li D,Li D,Liu J,Gao H,Zhang L,Lin J,Wang X

Fri Sep 01 00:00:00 UTC 2023

Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Li Y,Zhao R,Xiu Z,Yang X,Zhu Y,Han J,Li S,Li Y,Sun L,Li X,Jin N,Li Y

Tue Jul 25 00:00:00 UTC 2023

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.

Cancers

Zhang Y,Xu T,Tian H,Wu J,Yu X,Zeng L,Liu F,Liu Q,Huang X

Thu Dec 15 00:00:00 UTC 2022

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.

Cancers

Zhang Y,Xu T,Tian H,Wu J,Yu X,Zeng L,Liu F,Liu Q,Huang X

Thu Dec 15 00:00:00 UTC 2022

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.

Cancers

Zhang Y,Xu T,Tian H,Wu J,Yu X,Zeng L,Liu F,Liu Q,Huang X

Thu Dec 15 00:00:00 UTC 2022

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.

Cancers

Zhang Y,Xu T,Tian H,Wu J,Yu X,Zeng L,Liu F,Liu Q,Huang X

Thu Dec 15 00:00:00 UTC 2022

Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.

Cancer reports (Hoboken, N.J.)

Huang YL,Zhang GH,Zhu Q,Wu X,Wu LG

Thu Sep 01 00:00:00 UTC 2022

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.

Cell death discovery

Yao F,Jin Z,Zheng Z,Lv X,Ren L,Yang J,Chen D,Wang B,Yang W,Chen L,Wang W,Gu J,Lin R

Sat Mar 12 00:00:00 UTC 2022

JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.

Brain research bulletin

Zhong X,Chen Z,Wang Y,Mao M,Deng Y,Shi M,Xu Y,Chen L,Cao W

Sat Oct 15 00:00:00 UTC 2022

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

The Science of the total environment

Zhou J,Zeng L,Zhang Y,Wang M,Li Y,Jia Y,Wu L,Su P

Tue Nov 15 00:00:00 UTC 2022

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

The Science of the total environment

Zhou J,Zeng L,Zhang Y,Wang M,Li Y,Jia Y,Wu L,Su P

Tue Nov 15 00:00:00 UTC 2022

Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.

Frontiers in immunology

Khan M,Ai M,Du K,Song J,Wang B,Lin J,Ren A,Chen C,Huang Z,Qiu W,Zhang J,Tian Y,Yuan Y

Tue Jan 10 00:00:00 UTC 2023

Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.

Archives of toxicology

Mao X,Li J,Xie X,Chen S,Huang Q,Mu P,Jiang J,Deng Y

Tue Nov 01 00:00:00 UTC 2022

Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.

Archives of toxicology

Mao X,Li J,Xie X,Chen S,Huang Q,Mu P,Jiang J,Deng Y

Tue Nov 01 00:00:00 UTC 2022

Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.

Archives of toxicology

Mao X,Li J,Xie X,Chen S,Huang Q,Mu P,Jiang J,Deng Y

Tue Nov 01 00:00:00 UTC 2022

Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.

Archives of toxicology

Mao X,Li J,Xie X,Chen S,Huang Q,Mu P,Jiang J,Deng Y

Tue Nov 01 00:00:00 UTC 2022

GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.

Oxidative medicine and cellular longevity

Li F,Xia Q,Ren L,Nie Y,Ren H,Guo X,Yu J,Xing Y,Chen Z

Fri Apr 29 00:00:00 UTC 2022

GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.

Oxidative medicine and cellular longevity

Li F,Xia Q,Ren L,Nie Y,Ren H,Guo X,Yu J,Xing Y,Chen Z

Fri Apr 29 00:00:00 UTC 2022

Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.

Scientific reports

Kobayashi T,Mitsuhashi A,Hongying P,Shioya M,Kojima K,Nishikimi K,Yahiro K,Shozu M

Fri Jul 01 00:00:00 UTC 2022

Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.

Cancers

Liu J,Gao L,Zhu X,Geng R,Tao X,Xu H,Chen Z

Wed Nov 10 00:00:00 UTC 2021

Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.

Cancers

Liu J,Gao L,Zhu X,Geng R,Tao X,Xu H,Chen Z

Wed Nov 10 00:00:00 UTC 2021

A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway.

Journal of materials chemistry. B

Long Y,Wang Z,Fan J,Yuan L,Tong C,Zhao Y,Liu B

Wed May 12 00:00:00 UTC 2021

Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.

Frontiers in cell and developmental biology

Wu T,Zhang XP,Zhang Q,Zou YY,Ma JD,Chen LF,Zou YW,Xue JM,Ma RF,Chen Z,Dai L

Fri Mar 04 00:00:00 UTC 2022

Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.

Frontiers in cell and developmental biology

Wu T,Zhang XP,Zhang Q,Zou YY,Ma JD,Chen LF,Zou YW,Xue JM,Ma RF,Chen Z,Dai L

Fri Mar 04 00:00:00 UTC 2022

Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.

Cancer management and research

Huang Y,Zhang G,Zhu Q,Wu X,Wu L

Wed Apr 27 00:00:00 UTC 2022

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.

Cell death and differentiation

Li Y,Yuan Y,Huang ZX,Chen H,Lan R,Wang Z,Lai K,Chen H,Chen Z,Zou Z,Ma HB,Lan HY,Mak TW,Xu Y

Sun Aug 01 00:00:00 UTC 2021

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.

Diabetes, metabolic syndrome and obesity : targets and therapy

Wen S,Wang ZH,Zhang CX,Yang Y,Fan QL

Wed Apr 13 00:00:00 UTC 2022

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.

Diabetes, metabolic syndrome and obesity : targets and therapy

Wen S,Wang ZH,Zhang CX,Yang Y,Fan QL

Wed Apr 13 00:00:00 UTC 2022

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.

Diabetes, metabolic syndrome and obesity : targets and therapy

Wen S,Wang ZH,Zhang CX,Yang Y,Fan QL

Wed Apr 13 00:00:00 UTC 2022

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.

Diabetes, metabolic syndrome and obesity : targets and therapy

Wen S,Wang ZH,Zhang CX,Yang Y,Fan QL

Wed Apr 13 00:00:00 UTC 2022

Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.

Brain research bulletin

Liu Y,Wen D,Gao J,Xie B,Yu H,Shen Q,Zhang J,Jing W,Cong B,Ma C

Tue Sep 01 00:00:00 UTC 2020

Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter.

Frontiers in cell and developmental biology

Lu Y,Hou K,Li M,Wu X,Yuan S

Sat Aug 03 00:00:00 UTC 2024

Bioinformatics

Protein Aliases: deafness, autosomal dominant 5; deafness, autosomal dominant 5 homolog; Gasdermin-E; ICERE-1; Inversely correlated with estrogen receptor expression 1; Non-syndromic hearing impairment protein 5; Non-syndromic hearing impairment protein 5 homolog; nonsyndromic hearing impairment protein

View more View less

Gene Aliases: 2310037D07Rik; 4932441K13Rik; DFNA5; Dfna5h; EG14210; Fin15; GSDME; ICERE-1; ICERE1

View more View less

UniProt ID: (Human) O60443, (Mouse) Q9Z2D3

View more View less

Entrez Gene ID: (Human) 1687, (Mouse) 54722

View more View less

Process(es)

apoptotic process sensory perception of sound negative regulation of cell proliferation inner ear receptor cell differentiation positive regulation of intrinsic apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

DFNA5 Polyclonal Antibody

DFNA5 Antibody (13075-1-AP) in IHC (P)

Product Details

13075-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!