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Invitrogen
DGAT2 Polyclonal Antibody
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Product Details
PA5-18667
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KLEHPTQQDIDLYH) corresponding to the internal amino acids of DGAT2 (aa 346-360).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10983983
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diacylglycerol O-acyltransferase 2; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2; Diglyceride acyltransferase 2; DKFZp686A15125
Gene Aliases: ARAT; DGAT2; GS1999FULL; HMFN1045; UNQ738/PRO1433
UniProt ID: (Human) Q96PD7
Entrez Gene ID: (Human) 84649
glycerol metabolic process
positive regulation of triglyceride biosynthetic process
triglyceride biosynthetic process
lipid storage
low-density lipoprotein particle clearance
long-chain fatty-acyl-CoA metabolic process
cellular triglyceride homeostasis
acylglycerol acyl-chain remodeling
retinol metabolic process
cholesterol homeostasis
positive regulation of gluconeogenesis
negative regulation of fatty acid oxidation
diacylglycerol metabolic process
regulation of lipoprotein metabolic process
fatty acid homeostasis
fat pad development
cellular response to oleic acid
regulation of cholesterol metabolic process
regulation of plasma lipoprotein particle levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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