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Invitrogen
DGAT2 Polyclonal Antibody
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Product Details
PA5-69667
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human DGAT2 (aa 208-257)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2689612
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; diacylglycerol acyltransferase 2; Diacylglycerol O-acyltransferase 2; Diglyceride acyltransferase 2; DKFZp686A15125; retinol O-fatty-acyltransferase
Gene Aliases: 0610010B06Rik; ARAT; DGAT-2; Dgat2
UniProt ID: (Mouse) Q9DCV3
Entrez Gene ID: (Mouse) 67800
2-acylglycerol O-acyltransferase activity
diacylglycerol O-acyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
protein homodimerization activity
retinol O-fatty-acyltransferase activity
glycerol metabolic process
lipid metabolic process
triglyceride biosynthetic process
lipid storage
low-density lipoprotein particle clearance
long-chain fatty-acyl-CoA metabolic process
cellular triglyceride homeostasis
cholesterol homeostasis
diacylglycerol metabolic process
fatty acid homeostasis
fat pad development
cellular response to oleic acid
regulation of plasma lipoprotein particle levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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