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This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: 88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-gamma; Diacylglycerol kinase gamma; diacylglycerol kinase, gamma 3; diacylglycerol kinase, gamma 90kDa; diacylglyerol kinase gamma; Diglyceride kinase gamma
Gene Aliases: 2900055E17Rik; 90kDa; AI854428; DAGK3; DGK-GAMMA; DGKG; E430001K23Rik; mKIAA4131
UniProt ID: (Human) P49619, (Mouse) Q91WG7
Entrez Gene ID: (Human) 1608, (Mouse) 110197
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