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Product Details
PA5-101127
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DGKQ(Accession P52824), corresponding to amino acid residues Q800-V850.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850571
Product Specific Information
Antibody detects endogenous levels of total DAGK.
Target Information
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAG kinase theta; Dgk theta; DGK-theta; Diacylglycerol kinase theta; diacylglycerol kinase, delta (110 kDa); diacylglycerol kinase, theta 110kDa; Diglyceride kinase theta; testis tissue sperm-binding protein Li 38a
Gene Aliases: 110kDa; DAGK; DAGK4; DAGK7; Dgkd; DGKQ
UniProt ID: (Human) P52824, (Mouse) Q6P5E8
Entrez Gene ID: (Human) 1609, (Mouse) 110524
regulation of transcription from RNA polymerase II promoter
signal transduction
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phosphorylation
cAMP-mediated signaling
response to ATP
intracellular signal transduction
thrombin receptor signaling pathway
protein kinase C signaling
platelet activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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