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Invitrogen
DIO2 Polyclonal Antibody
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Product Details
PA5-65489
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human DIO2. Recombinant protein control fragment (Product #RP-106163).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2664293
Product Specific Information
Immunogen sequence: EWRRMLTSEGL RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP ERP
Highest antigen sequence identity to the following orthologs - mouse 80%, rat 51%.
Target Information
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine by outer ring deiodination to bioactive 3,3',5-triiodothyronine residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5DII; deiodinase-2; deiodonase-2; DIOII; thyroxine deiodinase; thyroxine deiodinase, type II; thyroxine type II; Type 2 DI; type 2 iodothyronine deiodinase; Type II iodothyronine deiodinase; Type-II 5'-deiodinase; type-II 5'deiodinase
Gene Aliases: 5DII; D2; DIO2; DIOII; ITDI2; SelY; TXDI2
UniProt ID: (Human) Q92813
Entrez Gene ID: (Human) 1734
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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