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DIRAS1 Polyclonal Antibody

DIRAS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DIRAS1 Antibody (12634-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human esophagus tissue slide using (Product # 12634-1-AP) (DIRAS1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

DIRAS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12634-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DIRAS1 Fusion Protein Ag3329 (1-198 aa encoded by BC030660)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPEQSNDYR VVVFGAGGVG KSSLVLRFVK GTFRDTYIPT IEDTYRQVIS CDKSVCTLQI TDTTGSHQFP AMQRLSISKG HAFILVFSVT SKQSLEELGP IYKLIVQIKG SVEDIPVMLV GNKCDETQRE VDTREAQAVA QEWKCAFMET SAKMNYNVKE LFQELLTLET RRNMSLNIDG KRSGKQKRTD RVKGKCTLM (1-198 aa encoded by BC030660 )

Target Information

DIRAS1 belongs to a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas.

Cancers

Rothhammer-Hampl T,Liesenberg F,Hansen N,Hoja S,Delic S,Reifenberger G,Riemenschneider MJ

Tue Oct 12 00:00:00 UTC 2021

RNAa and Vector-Mediated Overexpression of DIRAS1 Suppresses Tumor Growth and Migration in Renal Cell Carcinoma.

Molecular therapy. Nucleic acids

Xu X,Li J,Wang S,Zheng X,Xie L

Fri Sep 07 00:00:00 UTC 2018

RNAa and Vector-Mediated Overexpression of DIRAS1 Suppresses Tumor Growth and Migration in Renal Cell Carcinoma.

Molecular therapy. Nucleic acids

Xu X,Li J,Wang S,Zheng X,Xie L

Fri Sep 07 00:00:00 UTC 2018

RNAa and Vector-Mediated Overexpression of DIRAS1 Suppresses Tumor Growth and Migration in Renal Cell Carcinoma.

Molecular therapy. Nucleic acids

Xu X,Li J,Wang S,Zheng X,Xie L

Fri Sep 07 00:00:00 UTC 2018

RNAa and Vector-Mediated Overexpression of DIRAS1 Suppresses Tumor Growth and Migration in Renal Cell Carcinoma.

Molecular therapy. Nucleic acids

Xu X,Li J,Wang S,Zheng X,Xie L

Fri Sep 07 00:00:00 UTC 2018

Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.

International journal of environmental research and public health

Ma T,Yin X,Han R,Ding J,Zhang H,Han X,Li D

Tue Oct 24 00:00:00 UTC 2017

Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.

International journal of environmental research and public health

Ma T,Yin X,Han R,Ding J,Zhang H,Han X,Li D

Tue Oct 24 00:00:00 UTC 2017

Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.

International journal of environmental research and public health

Ma T,Yin X,Han R,Ding J,Zhang H,Han X,Li D

Tue Oct 24 00:00:00 UTC 2017

Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.

International journal of environmental research and public health

Ma T,Yin X,Han R,Ding J,Zhang H,Han X,Li D

Tue Oct 24 00:00:00 UTC 2017

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

The Journal of biological chemistry

Bergom C,Hauser AD,Rymaszewski A,Gonyo P,Prokop JW,Jennings BC,Lawton AJ,Frei A,Lorimer EL,Aguilera-Barrantes I,Mackinnon AC,Noon K,Fierke CA,Williams CL

Fri Mar 18 00:00:00 UTC 2016

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

The Journal of biological chemistry

Bergom C,Hauser AD,Rymaszewski A,Gonyo P,Prokop JW,Jennings BC,Lawton AJ,Frei A,Lorimer EL,Aguilera-Barrantes I,Mackinnon AC,Noon K,Fierke CA,Williams CL

Fri Mar 18 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: DIRAS family GTP binding RAS like 1; DIRAS family, GTP-binding RAS-like 1; Distinct subgroup of the Ras family member 1; GTP-binding protein Di-Ras1; Ras-related inhibitor of cell growth; Rig; Small GTP-binding tumor suppressor 1

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Gene Aliases: Di-Ras1; DIRAS1; GBTS1; RIG

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UniProt ID: (Human) O95057, (Mouse) Q91Z61

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Entrez Gene ID: (Human) 148252, (Rat) 366826, (Mouse) 208666

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Function(s)

GTPase activity GTP binding mitogen-activated protein kinase binding nucleotide binding

Process(es)

small GTPase mediated signal transduction positive regulation of MAP kinase activity metabolic process signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DIRAS1 Polyclonal Antibody

DIRAS1 Antibody (12634-1-AP) in IHC (P)

Product Details

12634-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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