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Invitrogen
DIS3L2 Polyclonal Antibody
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Product Details
PA5-31273
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DIS3L2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548747
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (90%), Rat (91%), Pig (93%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DIS3L2 encodes a protein that is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; DIS3L2; family with sequence similarity 6, member A; hDIS3L2
Gene Aliases: DIS3L2; FAM6A; hDIS3L2; PRLMNS
UniProt ID: (Human) Q8IYB7
Entrez Gene ID: (Human) 129563
nuclear-transcribed mRNA catabolic process, exonucleolytic
rRNA processing
mitotic nuclear division
negative regulation of cell proliferation
miRNA catabolic process
rRNA catabolic process
stem cell population maintenance
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
cell division
mitotic sister chromatid separation
RNA phosphodiester bond hydrolysis, exonucleolytic
polyuridylation-dependent mRNA catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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