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Invitrogen
DKK3 Monoclonal Antibody (4G7)
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Product Details
MA5-15601
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4G7
Immunogen
Purified recombinant fragment of human DKK3 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10981146
Product Specific Information
MA5-15601 targets DKK3 in indirect ELISA, FACS and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15601 immunogen is purified recombinant fragment of human DKK3 expressed in E. Coli.
MA5-15601 detects DKK3 which has a predicted molecular weight of approximately 38kDa.
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dickkopf3; DKK 3; dkk-3; hDkk 3; hDkk-3; hhDkk3; regulated in glioma; RIG-like 5-6; RIG-like 7-1; Xenopus
Gene Aliases: DKK3; REIC; RIG; UNQ258/PRO295
UniProt ID: (Human) Q9UBP4
Entrez Gene ID: (Human) 27122
anatomical structure morphogenesis
Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
adrenal gland development
negative regulation of aldosterone biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
negative regulation of anti-Mullerian hormone signaling pathway
negative regulation of cortisol biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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