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Invitrogen
DLD Recombinant Rabbit Monoclonal Antibody (3J2O9)
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Product Details
MA5-35680
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3J2O9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 401-500 of human DLDH/DLD (P09622)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849580
Product Specific Information
Immunogen sequence: WVGKSEEQLK EEGIEYKVGK FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI ARVCHAHPTL SEAFREANLA
Target Information
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: branched chain alpha-keto acid dehydrogenase complex subunit E3; diaphorase; Dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); Dihydrolipoyl dehydrogenase, mitochondrial; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; Glycine cleavage system L protein; glycine cleavage system protein L; lipoamide dehydrogenase; lipoamide reductase; lipoyl dehydrogenase; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PH; PHE 3
Gene Aliases: DLD; DLDD; DLDH; E3; GCSL; LAD; PHE3
UniProt ID: (Human) P09622, (Rat) Q6P6R2, (Mouse) O08749
Entrez Gene ID: (Human) 1738, (Rat) 298942, (Mouse) 13382
dihydrolipoyl dehydrogenase activity
pyruvate dehydrogenase (NAD+) activity
lipoamide binding
flavin adenine dinucleotide binding
NAD binding
mercury (II) reductase activity
mercury ion binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
acetyl-CoA biosynthetic process from pyruvate
2-oxoglutarate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
gastrulation
aging
lipoate metabolic process
regulation of membrane potential
cell redox homeostasis
sperm capacitation
detoxification of mercury ion
dihydrolipoamide metabolic process
oxidation-reduction process
pyruvate metabolic process
tricarboxylic acid cycle
lysine catabolic process
branched-chain amino acid catabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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