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Invitrogen
DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2), PE
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Product Details
MA5-28212
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Hamster
/ IgG
Class
Monoclonal
Type
Antibody
Clone
HMD4-2
Immunogen
Recombinant mouse DLL4
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. not determined
Purification
Protein G
Storage buffer
PBS with 5% sucrose, 1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745183
Product Specific Information
Reconstitute with 1.0 mL distilled water. Vial contains sample for 100 tests per 1 mL
Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.
Target Information
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344
Gene Aliases: Delta4; Dll4
UniProt ID: (Mouse) Q9JI71
Entrez Gene ID: (Mouse) 54485
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
blood vessel remodeling
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
pericardium morphogenesis
cell communication
Notch signaling pathway
multicellular organism development
nervous system development
visual perception
negative regulation of cell proliferation
negative regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
dorsal aorta morphogenesis
cellular response to vascular endothelial growth factor stimulus
negative regulation of blood vessel endothelial cell migration
cellular response to fibroblast growth factor stimulus
regulation of neurogenesis
response to stimulus
ventral spinal cord interneuron fate commitment
regulation of neural retina development
Notch signaling involved in heart development
blood vessel lumenization
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of neural precursor cell proliferation
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